The oxindole/imidazole derivative C16 reduces in vivo brain PKR activation.

The oxindole/imidazole derivative C16 reduces in vivo brain PKR activation. Research Abstract Details 

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The oxindole/imidazole derivative C16 reduces in vivo brain PKR activation. Abstract Text:

Sabrina Ingrand,Laurence Barrier,Claire Lafay-Chebassier,Bernard Fauconneau, Page,Jacques Hugon,Sabrina Ingrand,Laurence Barrier,Claire Lafay-Chebassier,Bernard Fauconneau, Page,Jacques Hugon,

Inhibition of double-stranded RNA-dependent protein kinase (PKR) represents an interesting strategy for neuroprotection. However, inhibiting this kinase which triggers the apoptotic process could favour in counterpart cell proliferation and tumorigenesis. Here, we use an in vivo model of 7-day-old rat displaying a high activation of brain PKR to investigate the effects of a new PKR inhibitor identified as an oxindole/imidazole derivative (C16). We show for the first time that acute systemic injection of C16 specifically inhibits the apoptotic PKR/eIF2alpha signaling pathway without stimulating the proliferative mTOR/p70S6K signaling mechanism.

The oxindole/imidazole derivative C16 reduces in vivo brain PKR activation. Publishing Authors By Initials

S Ingrand,L Barrier,C Lafay-Chebassier,B Fauconneau,G Page,J Hugon,S Ingrand,L Barrier,C Lafay-Chebassier,B Fauconneau,G Page,J Hugon,

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The oxindole/imidazole derivative C16 reduces in vivo brain PKR activation. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: FEBS letters

VOLUME: 581

Page Numbers: 4473-8

Journal Abbreviation: FEBS Lett.

ISSN: 0014-5793

DAY: 21

MONTH: 08

YEAR: 2007

The oxindole/imidazole derivative C16 reduces in vivo brain PKR activation. Information

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LANGUAGE: eng

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AFFILIATION: Research Group on Brain Aging (EA 3808), University of Poitiers, UFR Médecine-Pharmacie, 6 Rue de la Milétrie, BP 199, 86034 Poitiers Cedex, France. sabrina.ingrand@univ-poitiers.fr

Country: Netherlands

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MEDLINETA: FEBS Lett

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