The Ovhts polyprotein is cleaved to produce fusome and ring canal proteins required for Drosophila oogenesis.

The Ovhts polyprotein is cleaved to produce fusome and ring canal proteins required for Drosophila oogenesis. Research Abstract Details 

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The Ovhts polyprotein is cleaved to produce fusome and ring canal proteins required for Drosophila oogenesis. Abstract Text:

Lisa N Petrella,Tracy Smith-Leiker,Lynn Cooley,

An essential component of normal development is controlling the transition from cell proliferation to differentiation. One such transition occurs during Drosophila oogenesis. In early oogenesis, germ cells undergo mitotic proliferation and contain a specialized organelle called a fusome, whereas later post-mitotic cells differentiate and lose the fusome as F-actin-rich ring canals form. The hts gene encodes the only Drosophila Adducin, and is a female-sterile mutant that affects both the fusome and ring canals. We show that one Hts protein, Ovhts, is a polyprotein that is cleaved to produce two products, Ovhts-Fus and Ovhts-RC. Whereas Ovhts-Fus localizes to the fusome in mitotic cells, Ovhts-RC localizes to ring canals throughout later oogenesis. We demonstrate that an uncleavable version of Ovhts delays the transition from fusome-containing cells to those that have ring canals. Ovhts is the first polyprotein shown to produce proteins that function in separate structures.

The Ovhts polyprotein is cleaved to produce fusome and ring canal proteins required for Drosophila oogenesis. Publishing Authors By Initials

LN Petrella,T Smith-Leiker,L Cooley,

For similar proteins: polyproteins research abstracts see: proteins: polyproteins research

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The Ovhts polyprotein is cleaved to produce fusome and ring canal proteins required for Drosophila oogenesis. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Development (Cambridge, England)

VOLUME: 134

Page Numbers: 703-12

Journal Abbreviation: Development

ISSN: 0950-1991

DAY: 10

MONTH: 01

YEAR: 2007

The Ovhts polyprotein is cleaved to produce fusome and ring canal proteins required for Drosophila oogenesis. Information

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LANGUAGE: eng

NlmUniqueID: 8701744

The Ovhts polyprotein is cleaved to produce fusome and ring canal proteins required for Drosophila oogenesis. Keywords Mesh Terms:

KEYWORDS: Polyproteins

MESH TERMS: physiology

Chemical & Substance for Abstract: The Ovhts polyprotein is cleaved to produce fusome and ring canal proteins required for Drosophila oogenesis. Information

Substance Name: hu li tai shao protein, Drosophila

Registry Number: 0

Grant and Affiliation Information for The Ovhts polyprotein is cleaved to produce fusome and ring canal proteins required for Drosophila oogenesis.

AFFILIATION: Departments of Genetics, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA.

Country: England

AGENCY: United States NIGMS

GRANT: GM52702

ACRONYM: GM

MEDLINETA: Development

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