The outer membrane form of the mitochondrial protein Mcr1 follows a TOM-independent membrane insertion pathway.

The outer membrane form of the mitochondrial protein Mcr1 follows a TOM-independent membrane insertion pathway. Research Abstract Details 

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The outer membrane form of the mitochondrial protein Mcr1 follows a TOM-independent membrane insertion pathway. Abstract Text:

The yeast gene MCR1 encodes two isoforms of the mitochondrial NADH-cytochrome b5 reductase. One form is embedded in the outer membrane whereas the other is located in the intermembrane space (IMS). In the present work we investigated the biogenesis of the outer membrane form. We demonstrate that while the IMS form crosses the outer membrane via the translocase of the outer mitochondrial membrane (TOM) complex, the other form is integrated into the outer membrane by a process that does not require any of the known import components at the outer membrane. Thus, the import pathways of the two forms diverge in a stage before the encounter with the TOM complex and their mechanism of biogenesis represents a unique example how to achieve dual localization within one organelle.

The outer membrane form of the mitochondrial protein Mcr1 follows a TOM-independent membrane insertion pathway. Publishing Authors By Initials

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The outer membrane form of the mitochondrial protein Mcr1 follows a TOM-independent membrane insertion pathway. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: FEBS letters

VOLUME: 582

Page Numbers: 855-60

Journal Abbreviation: FEBS Lett.

ISSN: 0014-5793

DAY: 13

MONTH: 02

YEAR: 2008

The outer membrane form of the mitochondrial protein Mcr1 follows a TOM-independent membrane insertion pathway. Information

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LANGUAGE: eng

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Grant and Affiliation Information for The outer membrane form of the mitochondrial protein Mcr1 follows a TOM-independent membrane insertion pathway.

AFFILIATION: Interfaculty Institute for Biochemistry, Hoppe-Seyler-Strasse 4, University of Tübingen, 72076 Tübingen, Germany.

Country: Netherlands

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MEDLINETA: FEBS Lett

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