The opposing homeobox genes Goosecoid and Vent1/2 self-regulate Xenopus patterning.

The opposing homeobox genes Goosecoid and Vent1/2 self-regulate Xenopus patterning. Research Abstract Details 

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The opposing homeobox genes Goosecoid and Vent1/2 self-regulate Xenopus patterning. Abstract Text:

Veronika Sander,Bruno Reversade,E M De Robertis,Veronika Sander,Bruno Reversade,E M De Robertis,

We present a loss-of-function study using antisense morpholino (MO) reagents for the organizer-specific gene Goosecoid (Gsc) and the ventral genes Vent1 and Vent2. Unlike in the mouse Gsc is required in Xenopus for mesodermal patterning during gastrulation, causing phenotypes ranging from reduction of head structures-including cyclopia and holoprosencephaly-to expansion of ventral tissues in MO-injected embryos. The overexpression effects of Gsc mRNA require the expression of the BMP antagonist Chordin, a downstream target of Gsc. Combined Vent1 and Vent2 MOs strongly dorsalized the embryo. Unexpectedly, simultaneous depletion of all three genes led to a rescue of almost normal development in a variety of embryological assays. Thus, the phenotypic effects of depleting Gsc or Vent1/2 are caused by the transcriptional upregulation of their opposing counterparts. A principal function of Gsc and Vent1/2 homeobox genes might be to mediate a self-adjusting mechanism that restores the basic body plan when deviations from the norm occur, rather than generating individual cell types. The results may shed light on the molecular mechanisms of genetic redundancy.

The opposing homeobox genes Goosecoid and Vent1/2 self-regulate Xenopus patterning. Publishing Authors By Initials

V Sander,B Reversade,EM De Robertis,V Sander,B Reversade,EM De Robertis,

For similar proteins: amphibian proteins: xenopus proteins research abstracts see: proteins: amphibian proteins: xenopus proteins research

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The opposing homeobox genes Goosecoid and Vent1/2 self-regulate Xenopus patterning. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: The EMBO journal

VOLUME: 26

Page Numbers: 2955-65

Journal Abbreviation: EMBO J.

ISSN: 0261-4189

DAY: 24

MONTH: 05

YEAR: 2007

The opposing homeobox genes Goosecoid and Vent1/2 self-regulate Xenopus patterning. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8208664

The opposing homeobox genes Goosecoid and Vent1/2 self-regulate Xenopus patterning. Keywords Mesh Terms:

KEYWORDS: Xenopus Proteins

MESH TERMS: genetics

Chemical & Substance for Abstract: The opposing homeobox genes Goosecoid and Vent1/2 self-regulate Xenopus patterning. Information

Substance Name: chordin

Registry Number: 93586-27-7

Grant and Affiliation Information for The opposing homeobox genes Goosecoid and Vent1/2 self-regulate Xenopus patterning.

AFFILIATION: Howard Hughes Medical Institute and Department of Biological Chemistry, University of California-Los Angeles, 675 Charles Young Drive South, Los Angeles, CA 90095, USA.

Country: England

AGENCY: United States NICHD

GRANT: R37 HD 21502-21

ACRONYM: HD

MEDLINETA: EMBO J

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