The obligate human pathogen, Neisseria gonorrhoeae, is polyploid.

The obligate human pathogen, Neisseria gonorrhoeae, is polyploid. Research Abstract Details 

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The obligate human pathogen, Neisseria gonorrhoeae, is polyploid. Abstract Text:

Deborah M Tobiason,H Steven Seifert,Deborah M Tobiason,H Steven Seifert,

We show using several methodologies that the Gram-negative, diplococcal-bacterium Neisseria gonorrhoeae has more than one complete genome copy per cell. Gene dosage measurements demonstrated that only a single replication initiation event per chromosome occurs per round of cell division, and that there is a single origin of replication. The region containing the origin does not encode any genes previously associated with bacterial origins of replication. Quantitative PCR results showed that there are on average three genome copies per coccal cell unit. These findings allow a model for gonococcal DNA replication and cell division to be proposed, in which a minimum of two chromosomal copies exist per coccal unit within a monococcal or diplococcal cell, and these chromosomes replicate in unison to produce four chromosomal copies during cell division. Immune evasion via antigenic variation is an important mechanism that allows these organisms to continually infect a high risk population of people. We propose that polyploidy may be necessary for the high frequency gene conversion system that mediates pilin antigenic variation and the propagation of N. gonorrhoeae within its human hosts.

The obligate human pathogen, Neisseria gonorrhoeae, is polyploid. Publishing Authors By Initials

DM Tobiason,HS Seifert,DM Tobiason,HS Seifert,

For similar genetic phenomena: ploidies: polyploidy research abstracts see: genetic phenomena: ploidies: polyploidy research

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The obligate human pathogen, Neisseria gonorrhoeae, is polyploid. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: PLoS biology

VOLUME: 4

Page Numbers: e185

Journal Abbreviation: PLoS Biol.

ISSN: 1545-7885

DAY: 3

MONTH: Jun

YEAR: 2006

The obligate human pathogen, Neisseria gonorrhoeae, is polyploid. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 101183755

The obligate human pathogen, Neisseria gonorrhoeae, is polyploid. Keywords Mesh Terms:

KEYWORDS: Polyploidy

MESH TERMS: pathogenicity

Chemical & Substance for Abstract: The obligate human pathogen, Neisseria gonorrhoeae, is polyploid. Information

Substance Name: DNA, Bacterial

Registry Number: 0

Grant and Affiliation Information for The obligate human pathogen, Neisseria gonorrhoeae, is polyploid.

AFFILIATION: Department of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.

Country: United States

AGENCY: United States NIAID

GRANT: R37 AI033493

ACRONYM: AI

MEDLINETA: PLoS Biol

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