The nucleation of inosine: the impact of solution chemistry on the appearance of polymorphic and hydrated crystal forms.

The nucleation of inosine: the impact of solution chemistry on the appearance of polymorphic and hydrated crystal forms. Research Abstract Details 

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The nucleation of inosine: the impact of solution chemistry on the appearance of polymorphic and hydrated crystal forms. Abstract Text:

Renato A Chiarella,Amy L Gillon,Rebecca C Burton,Roger J Davey,Ghazala Sadiq,Anthony Auffret,Marina Cioffi,Christopher A Hunter,

This contribution concerns the issue of crystal nucleation in the polymorphic and hydrate forming system inosine-water. A combination of computational and experimental tools have been used to explore the relationship between solution phase inosine species and the structural synthons as found in its crystal structures. It is evident that the initial nucleation of a metastable polymorph at temperatures above 10 degrees C is directed by dimeric self-association as revealed through proton NMR. At lower temperatures a dihydrate structure becomes the most stable solid phase and in this region of the phase diagram this is the only form that appears even though the solution species remain unchanged. This can only be rationalised in terms of a combination of water binding to the solution dimers and the thermodynamic stability of the hydrate crystal structure.

The nucleation of inosine: the impact of solution chemistry on the appearance of polymorphic and hydrated crystal forms. Publishing Authors By Initials

RA Chiarella,AL Gillon,RC Burton,RJ Davey,G Sadiq,A Auffret,M Cioffi,CA Hunter,

For similar water research abstracts see: water research

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The nucleation of inosine: the impact of solution chemistry on the appearance of polymorphic and hydrated crystal forms. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Faraday discussions

VOLUME: 136

Page Numbers: 179-93; discussion 213-29

Journal Abbreviation: Faraday Discuss.

ISSN: 1359-6640

DAY: 28

MONTH: 11

YEAR: 2007

The nucleation of inosine: the impact of solution chemistry on the appearance of polymorphic and hydrated crystal forms. Information

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LANGUAGE: eng

NlmUniqueID: 9212301

The nucleation of inosine: the impact of solution chemistry on the appearance of polymorphic and hydrated crystal forms. Keywords Mesh Terms:

KEYWORDS: Water

MESH TERMS: chemistry

Chemical & Substance for Abstract: The nucleation of inosine: the impact of solution chemistry on the appearance of polymorphic and hydrated crystal forms. Information

Substance Name: Water

Registry Number: 7732-18-5

Grant and Affiliation Information for The nucleation of inosine: the impact of solution chemistry on the appearance of polymorphic and hydrated crystal forms.

AFFILIATION: Colloids Crystals and Interfaces Group, School of Chemical Engineering and Analytical Sciences, University of Manchester, P.O. Box 88, Manchester, UK M60 1QD.

Country: England

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MEDLINETA: Faraday Discuss

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