[The Nobel Prize in Physiology or Medicine for 2006 for the discovery of RNA interference]

[The Nobel Prize in Physiology or Medicine for 2006 for the discovery of RNA interference] Research Abstract Details 

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[The Nobel Prize in Physiology or Medicine for 2006 for the discovery of RNA interference] Abstract Text:

R Bernards,

The Nobel Prize in Physiology or Medicine has been awarded to Andrew Fire and Craig Mello for their discovery of RNA interference, i.e. the suppression of gene activity by double-stranded RNA. Small interfering RNA molecules (siRNAs), notably the antisense strand, recognise and inhibit the corresponding mRNA, thereby silencing the appropriate gene. RNA interference can help to determine the function of genes and may assist in the development ofnew drugs. It may also lead to a better understanding of mechanisms of drug resistance. In addition, siRNAs themselves may prove to have therapeutic value as many diseases are the result of alterations in gene activity.

[The Nobel Prize in Physiology or Medicine for 2006 for the discovery of RNA interference] Publishing Authors By Initials

R Bernards,

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[The Nobel Prize in Physiology or Medicine for 2006 for the discovery of RNA interference] Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Nederlands tijdschrift voor geneeskunde

VOLUME: 150

Page Numbers: 2849-53

Journal Abbreviation:

ISSN: 0028-2162

DAY: 30

MONTH: Dec

YEAR: 2006

[The Nobel Prize in Physiology or Medicine for 2006 for the discovery of RNA interference] Information

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LANGUAGE: dut

NlmUniqueID: 400770

[The Nobel Prize in Physiology or Medicine for 2006 for the discovery of RNA interference] Keywords Mesh Terms:

KEYWORDS: United States

MESH TERMS: genetics

Chemical & Substance for Abstract: [The Nobel Prize in Physiology or Medicine for 2006 for the discovery of RNA interference] Information

Substance Name: RNA, Small Interfering

Registry Number: 0

Grant and Affiliation Information for [The Nobel Prize in Physiology or Medicine for 2006 for the discovery of RNA interference]

AFFILIATION: Nederlands Kanker Instituut-Antoni van Leeuwenhoek Ziekenhuis, afd. Moleculaire Carcinogenese, Amsterdam. r.bernards@nki.nl

Country: Netherlands

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MEDLINETA: Ned Tijdschr Geneeskd

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