The neurobiology of aggression and rage: role of cytokines.

The neurobiology of aggression and rage: role of cytokines. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

The neurobiology of aggression and rage: role of cytokines. Abstract Text:

Steven S Zalcman,Allan Siegel,

Recent studies have suggested an important relationship linking cytokines, immunity and aggressive behavior. Clinical reports describe increasing levels of hostility, anger, and irritability in patients who receive cytokine immunotherapy, and there are reports of a positive correlation between cytokine levels and aggressive behavior in non-patient populations. On the basis of these reports and others describing the presence or actions of different cytokines in regions of the brain associated with aggressive behavior, our laboratory embarked upon a program of research designed to identify and characterize the role of IL-1 and IL-2 in the hypothalamus and midbrain periaqueductal gray (PAG)--two regions functionally linked through reciprocal anatomical connections--in the regulation of feline defensive rage. A paradigm involved cytokine microinjections into either medial hypothalamus and elicitation of defensive rage behavior from the PAG or vice versa. These studies have revealed that both cytokines have potent effects in modulating defensive rage behavior. With respect to IL-1, this cytokine facilitates defensive rage when microinjected into either the medial hypothalamus or PAG and these potentiating effects are mediated through 5-HT2 receptors. In contrast, the effects of IL-2 are dependent upon the anatomical locus. IL-2 microinjected into the medial hypothalamus suppresses defensive rage and this suppression is mediated through GABA(A) receptors, while microinjections of IL-2 in the PAG potentiate defensive rage, in which these effects are mediated through NK-1 receptors. Present research is designed to further delineate the roles of cytokines in aggressive behavior and to begin to unravel the possible signaling pathways involved this process.

The neurobiology of aggression and rage: role of cytokines. Publishing Authors By Initials

SS Zalcman,A Siegel,

For similar behavior and behavior mechanisms: emotions: anger: rage research abstracts see: behavior and behavior mechanisms: emotions: anger: rage research

PUBMED ID PMID:

MEDLINE DATE:

The neurobiology of aggression and rage: role of cytokines. Journal Published:

PUBLICATION TYPE: Review

Journal: Brain, behavior, and immunity

VOLUME: 20

Page Numbers: 507-14

Journal Abbreviation: Brain Behav. Immun.

ISSN: 0889-1591

DAY: 30

MONTH: 08

YEAR: 2006

The neurobiology of aggression and rage: role of cytokines. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8800478

The neurobiology of aggression and rage: role of cytokines. Keywords Mesh Terms:

KEYWORDS: Rage

MESH TERMS: physiology

Chemical & Substance for Abstract: The neurobiology of aggression and rage: role of cytokines. Information

Substance Name: Interleukin-2

Registry Number: 0

Grant and Affiliation Information for The neurobiology of aggression and rage: role of cytokines.

AFFILIATION: Department of Psychiatry, UMDNJ-New Jersey Medical School, Newark, NJ 07103, USA. zalcmass@umdnj.edu

Country: United States

AGENCY: United States NINDS

GRANT: NS 07941-34

ACRONYM: NS

MEDLINETA: Brain Behav Immun

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

The neurobiology of aggression and rage: role of cytokines Related Publications

• Anti-TGF-beta2 antibody therapy inhibits postoperative resynostosis in craniosynostotic rabbits.
• Association of PSD-95 with ErbB4 facilitates neuregulin signaling in cerebellar granule neurons in culture.
• At what age can children report dependably on their asthma health status?
• Attentional modulation of receptive field structure in area 7a of the behaving monkey.
• Autoimmunity versus tolerance: can dying cells tip the balance?
• Effect of the ovulatory cycle on oviductal sperm storage in the domestic fowl.
• Effects of glossopharyngeal insufflation on cardiac function: an echocardiographic study in elite breath-hold divers.
• Fighting cancer with fitness: dietary outcomes of a randomized, controlled lifestyle change intervention in healthy African-American women.
• Hypocretin (orexin) cell loss in Parkinson's disease.
• Informatics in radiology: GridCAD: grid-based computer-aided detection system.
• Integration of hydrogels with hard and soft microstructures.
• Large germline deletions and duplication in isolated cerebral cavernous malformation patients.
• MDCT of tracheobronchial narrowing in pediatric patients.
• Mecamylamine blocks nicotine-induced enhancement of the P20 auditory event-related potential and evoked gamma.
• MedlinePlus and the challenge of low health literacy: findings from the Colonias project.
• Mortality partitions and their relevance to research on senescence.
• Onset of puberty in CD-1 mouse pups exposed prenatally through weaning to endophyte-infected tall fescue seed.
• Oxidation of 2-mercaptobenzothiazole in latex gloves and its possible haptenation pathway.
• Phage display-based molecular methods in immunohematology.
• Pharmacokinetic and behavioral characterization of a long-term antipsychotic delivery system in rodents and rabbits.
• Pneumonitis in human cytomegalovirus infection.
• Postoperative anti-Tgf-beta2 antibody therapy improves intracranial volume and craniofacial growth in craniosynostotic rabbits.
• Premature carotid artery disease in long-term survivors of childhood cancer treated with neck irradiation: a series of 5 cases.
• Reproducibility of platelet function testing.
• Sexual violence inside prisons: rates of victimization.
• Stress and health: psychological, behavioral, and biological determinants.
• The effects of yoga practice on psychological well-being: 2426: board #105 june 1 3:30 PM -5:00 PM.
• The neurobiology of aggression and rage: role of cytokines.
• Trends in the inpatient mental health treatment of children and adolescents in US community hospitals between 1990 and 2000.
• Yield of brain 18F-FDG PET in evaluating patients with potentially operable non-small cell lung cancer.