The NBS1-ATM connection revisited.

The NBS1-ATM connection revisited. Research Abstract Details 

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The NBS1-ATM connection revisited. Abstract Text:

Simone Difilippantonio, Nussenzweig,Simone Difilippantonio, Nussenzweig,

Nijmegen Breakage syndrome (NBS) is a rare autosomal recessive disorder characterized by microcephaly, immunodeficiency, and increased predisposition to the development of malignancy. Due to the overlap of clinical and cellular features of patients with ataxia telangiectasia (AT), NBS was described as an AT variant syndrome until the underlying gene product mutation was identified. Cells from both AT and NBS patients show increased sensitivity to ionizing radiation (IR), genomic instability and cell cycle checkpoint defects following DNA damage, suggesting that both gene products participate in the same DNA damage response pathway. Here we highlight recent developments and refinements in our understanding of the interplay between NBS1 and ATM in vivo.

The NBS1-ATM connection revisited. Publishing Authors By Initials

S Difilippantonio,A Nussenzweig,S Difilippantonio,A Nussenzweig,

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The NBS1-ATM connection revisited. Journal Published:

PUBLICATION TYPE: Review

Journal: Cell cycle (Georgetown, Tex.)

VOLUME: 6

Page Numbers: 2366-70

Journal Abbreviation: Cell Cycle

ISSN: 1551-4005

DAY: 18

MONTH: 07

YEAR: 2007

The NBS1-ATM connection revisited. Information

Number of References: 67

LANGUAGE: eng

NlmUniqueID: 101137841

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Grant and Affiliation Information for The NBS1-ATM connection revisited.

AFFILIATION: Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA. DifilipS@mail.nih.gov

Country: United States

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MEDLINETA: Cell Cycle

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