The natural history of chronic hepatitis B.

The natural history of chronic hepatitis B. Research Abstract Details 

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The natural history of chronic hepatitis B. Abstract Text:

C-L Lai,M-F Yuen,C-L Lai,M-F Yuen,

The natural history of chronic hepatitis B is dependent on the age of acquiring the hepatitis B infection. Those who are infected at adolescence or adulthood (including most of the Caucasians) tend to have stable disease after hepatitis B e antigen seroconversion with normal serum alanine aminotransaminase (ALT) and hepatitis B virus (HBV) DNA levels <10(5) copies/mL (20 000 IU/mL). In contrast, those who are infected at birth or early childhood (including the majority of the world's hepatitis B carriers, i.e. Asians) have a prolonged immune tolerance phase followed by a prolonged immune clearance phase. A proportion of these patients have progressive disease after HBeAg seroconversion with HBV DNA <10(4) copies/mL (<2000 IU/mL) and ALT between 0.5 and 2x upper limit of normal. Core promoter mutations may play a part in the development of cirrhosis-related complications. However, continuing viral replication, even at a relatively low level of <10(4) copies/mL (<2000 IU/mL), is probably the most important factor for the development of complications.

The natural history of chronic hepatitis B. Publishing Authors By Initials

CL Lai,MF Yuen,CL Lai,MF Yuen,

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The natural history of chronic hepatitis B. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of viral hepatitis

VOLUME: 14 Suppl 1

Page Numbers: 6-10

Journal Abbreviation: J. Viral Hepat.

ISSN: 1352-0504

DAY: 25

MONTH: Nov

YEAR: 2007

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LANGUAGE: eng

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AFFILIATION: Department of Medicine, The University of Hong Kong, Hong Kong. hrmelcl@hkucc.hku.hk

Country: England

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MEDLINETA: J Viral Hepat

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