The MUC2 gene product: a human intestinal mucin.

The MUC2 gene product: a human intestinal mucin. Research Abstract Details 

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The MUC2 gene product: a human intestinal mucin. Abstract Text:

A Allen,D A Hutton,J P Pearson,

The MUC2 gene product is the first human secretory mucin protein core to be fully sequenced. Like the other eight human MUC genes identified to date, MUC2 is characterised by tandem and irregular repeat sequences rich in threonine and serine, the potential sites of attachment of the oligosaccharide chains. The MUC2 gene product is more than 5100 amino acids in its commonest allelic form and accounts for one fifth by weight of the mucin glycoprotein molecule (80% oligosaccharide side chains). The MUC2 product is polymerised end to end through disulphide bridges to form large secreted polymeric gel-forming mucins (Mr approximately 10(7)). The primary function of the MUC2 gene product is to provide a protective barrier between the epithelial surfaces and the gut lumen. There is decreased expression of MUC2 in colonic cancer and defective polymerisation of secreted mucin in ulcerative colitis. Elucidation of the MUC2 and other mucin gene sequences has opened the way for a full structural characterisation and an improved understanding of the structure and function of these complex mucus gel secretions.

The MUC2 gene product: a human intestinal mucin. Publishing Authors By Initials

A Allen,DA Hutton,JP Pearson,

For similar biochemical phenomena, metabolism, and nutrition: biochemical phenomena: molecular structure: base sequence: repetitive sequences, nucleic acid research abstracts see: biochemical phenomena, metabolism, and nutrition: biochemical phenomena: molecular structure: base sequence: repetitive sequences, nucleic acid research

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The MUC2 gene product: a human intestinal mucin. Journal Published:

PUBLICATION TYPE: Review

Journal: The international journal of biochemistry & cell b

VOLUME: 30

Page Numbers: 797-801

Journal Abbreviation: Int. J. Biochem. Cell Biol.

ISSN: 1357-2725

DAY: 30

MONTH: Jul

YEAR: 1998

The MUC2 gene product: a human intestinal mucin. Information

Number of References: 16

LANGUAGE: eng

NlmUniqueID: 9508482

The MUC2 gene product: a human intestinal mucin. Keywords Mesh Terms:

KEYWORDS: Repetitive Sequences, Nucleic Acid

MESH TERMS: physiology

Chemical & Substance for Abstract: The MUC2 gene product: a human intestinal mucin. Information

Substance Name: Mucins

Registry Number: 0

Grant and Affiliation Information for The MUC2 gene product: a human intestinal mucin.

AFFILIATION: Department of Physiological Sciences, Medical School, University of Newcastle upon Tyne, UK. a.allen@ncl.ac.uk

Country: ENGLAND

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MEDLINETA: Int J Biochem Cell Biol

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