The mouse homolog of HEN1 is a potential methylase for Piwi-interacting RNAs.

The mouse homolog of HEN1 is a potential methylase for Piwi-interacting RNAs. Research Abstract Details 

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The mouse homolog of HEN1 is a potential methylase for Piwi-interacting RNAs. Abstract Text:

Yohei Kirino,Zissimos Mourelatos,

Piwi-interacting RNAs (piRNAs) are a novel class of small regulatory RNAs that are expressed specifically and abundantly in germ cells. Mammalian piRNAs are 26-31 nucleotides in length and bind to Piwi proteins, but their function and biogenesis remain elusive. We previously showed that mammalian piRNAs are 2'-O-methylated at their 3' termini. The biosynthetic mechanism and function of this modification is unknown. Here, we report that the mouse homolog (mHEN1) of HEN1, a plant microRNA (miRNA) 2'-O-methyltransferase, is expressed specifically in testis and methylates 3' termini of piRNAs in vitro. These findings provide insight into the biogenesis of piRNAs.

The mouse homolog of HEN1 is a potential methylase for Piwi-interacting RNAs. Publishing Authors By Initials

Y Kirino,Z Mourelatos,

For similar urogenital system: genitalia: genitalia, male: testis research abstracts see: urogenital system: genitalia: genitalia, male: testis research

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The mouse homolog of HEN1 is a potential methylase for Piwi-interacting RNAs. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: RNA (New York, N.Y.)

VOLUME: 13

Page Numbers: 1397-401

Journal Abbreviation: RNA

ISSN: 1355-8382

DAY: 24

MONTH: 07

YEAR: 2007

The mouse homolog of HEN1 is a potential methylase for Piwi-interacting RNAs. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9509184

The mouse homolog of HEN1 is a potential methylase for Piwi-interacting RNAs. Keywords Mesh Terms:

KEYWORDS: Testis

MESH TERMS: enzymology

Chemical & Substance for Abstract: The mouse homolog of HEN1 is a potential methylase for Piwi-interacting RNAs. Information

Substance Name: RNA 2'-O-methyltransferase

Registry Number: EC 2.1.1.-

Grant and Affiliation Information for The mouse homolog of HEN1 is a potential methylase for Piwi-interacting RNAs.

AFFILIATION:

Country: United States

AGENCY: United States NICHD

GRANT: P30-HD026979

ACRONYM: HD

MEDLINETA: RNA

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