The mouse Engrailed genes: a window into autism.

The mouse Engrailed genes: a window into autism. Research Abstract Details 

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The mouse Engrailed genes: a window into autism. Abstract Text:

Barbara Kuemerle,Forrest Gulden,Natalie Cherosky,Elizabeth Williams,Karl Herrup,

The complex behavioral symptoms and neuroanatomical abnormalities observed in autistic individuals strongly suggest a multi-factorial basis for this perplexing disease. Although not the perfect model, we believe the Engrailed genes provide an invaluable "window" into the elusive etiology of autism spectrum disorder. The Engrailed-2 gene has been associated with autism in genetic linkage studies. The En2 knock-out mouse harbors cerebellar abnormalities that are similar to those found in autistic individuals and, as we report here, has a distinct anterior shift in the position of the amygdala in the cerebral cortex. Our initial analysis of background effects in the En1 mouse knock-out provides insight as to possible molecular mechanisms and gender differences associated with autism. These findings further the connection between Engrailed and autism and provide new avenues to explore in the ongoing study of the biological basis of this multifaceted disease.

The mouse Engrailed genes: a window into autism. Publishing Authors By Initials

B Kuemerle,F Gulden,N Cherosky,E Williams,K Herrup,

For similar behavior and behavior mechanisms: behavior: social behavior research abstracts see: behavior and behavior mechanisms: behavior: social behavior research

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The mouse Engrailed genes: a window into autism. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Behavioural brain research

VOLUME: 176

Page Numbers: 121-32

Journal Abbreviation: Behav. Brain Res.

ISSN: 0166-4328

DAY: 20

MONTH: 10

YEAR: 2006

The mouse Engrailed genes: a window into autism. Information

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LANGUAGE: eng

NlmUniqueID: 8004872

The mouse Engrailed genes: a window into autism. Keywords Mesh Terms:

KEYWORDS: Social Behavior

MESH TERMS: metabolism

Chemical & Substance for Abstract: The mouse Engrailed genes: a window into autism. Information

Substance Name: engrailed 2 protein

Registry Number: 0

Grant and Affiliation Information for The mouse Engrailed genes: a window into autism.

AFFILIATION: Department of Neuroscience, Case Western Reserve School of Medicine, Cleveland, OH 44106, USA.

Country: Netherlands

AGENCY: United States NINDS

GRANT: NS18381

ACRONYM: NS

MEDLINETA: Behav Brain Res

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