The molecular nature of zebrafish swirl: BMP2 function is essential during early dorsoventral patterning.

The molecular nature of zebrafish swirl: BMP2 function is essential during early dorsoventral patterning. Research Abstract Details 

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The molecular nature of zebrafish swirl: BMP2 function is essential during early dorsoventral patterning. Abstract Text:

Y Kishimoto,K H Lee,L Zon,M Hammerschmidt,S Schulte-Merker,

Early dorsoventral pattern formation in vertebrate embryos is regulated by opposing activities of ventralizing bone morphogenetic proteins (BMPs) and dorsal-specific BMP antagonists such as Chordin, Noggin and Follistatin. Specific defects in early dorsoventral patterning have been recently found in a number of zebrafish mutants, which exhibit either a ventralized or dorsalized phenotype. One of these, the ventralized mutant chordino (originally called dino) is caused by a mutation in the zebrafish chordin homologue and interacts genetically with the dorsalized mutant swirl. In swirl mutant embryos, dorsal structures such as notochord and somites are expanded while ventral structures such as blood and nephros are missing. Here we demonstrate that the swirl phenotype is caused by mutations in the zebrafish bmp2 gene (zbmp2). While injection of mRNAs encoded by the mutant alleles has no ventralizing effect, injection of wild-type zbmp2 mRNA leads to a complete rescue of the swirl mutant phenotype. Fertile adult mutant fish were obtained, showing that development after gastrulation is not dependent on zbmp2 function. In addition zBMP2 has no maternal role in mesoderm induction. Our analysis shows that swirl/BMP2, unlike mouse BMP2 but like mouse BMP4, is required for early dorsoventral patterning of the zebrafish embryo.

The molecular nature of zebrafish swirl: BMP2 function is essential during early dorsoventral patterning. Publishing Authors By Initials

Y Kishimoto,KH Lee,L Zon,M Hammerschmidt,S Schulte-Merker,

For similar animals: chordata: vertebrates: fishes: cypriniformes: cyprinidae: zebrafish research abstracts see: animals: chordata: vertebrates: fishes: cypriniformes: cyprinidae: zebrafish research

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The molecular nature of zebrafish swirl: BMP2 function is essential during early dorsoventral patterning. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Development (Cambridge, England)

VOLUME: 124

Page Numbers: 4457-66

Journal Abbreviation: Development

ISSN: 0950-1991

DAY: 19

MONTH: Nov

YEAR: 1997

The molecular nature of zebrafish swirl: BMP2 function is essential during early dorsoventral patterning. Information

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LANGUAGE: eng

NlmUniqueID: 8701744

The molecular nature of zebrafish swirl: BMP2 function is essential during early dorsoventral patterning. Keywords Mesh Terms:

KEYWORDS: Zebrafish

MESH TERMS: metabolism

Chemical & Substance for Abstract: The molecular nature of zebrafish swirl: BMP2 function is essential during early dorsoventral patterning. Information

Substance Name: chordin

Registry Number: 93586-27-7

Grant and Affiliation Information for The molecular nature of zebrafish swirl: BMP2 function is essential during early dorsoventral patterning.

AFFILIATION: MPI für Entwicklungsbiologie, Tübingen, Germany.

Country: ENGLAND

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MEDLINETA: Development

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