The molecular basis of antibody-mediated neutralization of West Nile virus.

The molecular basis of antibody-mediated neutralization of West Nile virus. Research Abstract Details 

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The molecular basis of antibody-mediated neutralization of West Nile virus. Abstract Text:

Theodore Oliphant,Michael S Diamond,

The study of the interaction between the West Nile virus envelope protein and monoclonal antibodies has provided insight into the molecular mechanisms of neutralization. Structural studies have identified an epitope on the lateral ridge of domain III of the West Nile virus E protein that is recognized by antibodies with the strongest neutralizing activity in vitro and in vivo. Antibodies that bind to this epitope are particularly inhibitory because they block infection at a post-attachment step and at concentrations that result in a low occupancy of the available sites on the virion.

The molecular basis of antibody-mediated neutralization of West Nile virus. Publishing Authors By Initials

T Oliphant,MS Diamond,

For similar viruses: rna viruses: flaviviridae: flavivirus: encephalitis viruses, japanese: west nile virus research abstracts see: viruses: rna viruses: flaviviridae: flavivirus: encephalitis viruses, japanese: west nile virus research

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The molecular basis of antibody-mediated neutralization of West Nile virus. Journal Published:

PUBLICATION TYPE: Review

Journal: Expert opinion on biological therapy

VOLUME: 7

Page Numbers: 885-92

Journal Abbreviation:

ISSN: 1744-7682

DAY: 3

MONTH: Jun

YEAR: 2007

The molecular basis of antibody-mediated neutralization of West Nile virus. Information

Number of References: 92

LANGUAGE: eng

NlmUniqueID: 101125414

The molecular basis of antibody-mediated neutralization of West Nile virus. Keywords Mesh Terms:

KEYWORDS: West Nile virus

MESH TERMS: immunology

Chemical & Substance for Abstract: The molecular basis of antibody-mediated neutralization of West Nile virus. Information

Substance Name: West Nile Virus Vaccines

Registry Number: 0

Grant and Affiliation Information for The molecular basis of antibody-mediated neutralization of West Nile virus.

AFFILIATION: Washington University School of Medicine, Department of Molecular Microbiology, Saint Louis, MO 63110, USA.

Country: England

AGENCY: United States NIAID

GRANT: U54 AI057160

ACRONYM: AI

MEDLINETA: Expert Opin Biol Ther

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