[The modulation of pilose antler extract (PAE) on the proliferation of rat osteogenic cells UMR-106]

[The modulation of pilose antler extract (PAE) on the proliferation of rat osteogenic cells UMR-106] Research Abstract Details 

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[The modulation of pilose antler extract (PAE) on the proliferation of rat osteogenic cells UMR-106] Abstract Text:

Xiao-chao Chen,Li-jing Ke,Gong-rui Chen,Shu-tao Liu,Yu-shu Huo,Ping-fan Rao,

OBJECTIVE: To investigate the modulation of pilose antler extract (PAE) on rat osteogenic cells UMR-106 in vitro. METHOD: Component P2 of PAE was isolated by Sephacryl S-200HR gel filtration chromatography. The proliferative effects of P2 and other components isolated by Sephacryl S-200HR on UMR-106 cells were investigated by MTT assay. RESULT: The P2 could significantly increase the proliferation rate of osteogenic cells. When the protein concentration of P2 was between 0.972 mg x L(-1) and 97.2 mg x L(-1), it could inhibit the proliferation of UMR-106 cells. But while the concentration was equal to or greater than 97.2 mg x L(-1), the P2 could increase the proliferation rate of cells, especially 477.92% at 9.72 g x L(-1), which was approximated to 499.62% of PAE. The molecular weight of the P2 was about 59 kDa determined by SDS-PAGE. On the other hand, inhibition was also observed in the sample of the P3, P4 and P5. CONCLUSION: Those regulative factors in PAE which have different molecular weight can affect the proliferation of UMR-106 cells two-wayly. And this adjustment also relies on the dose of those factors. This finding may help us to understand the possible mechanism of Chinese traditional medicine from animal materials.

[The modulation of pilose antler extract (PAE) on the proliferation of rat osteogenic cells UMR-106] Publishing Authors By Initials

XC Chen,LJ Ke,GR Chen,ST Liu,YS Huo,PF Rao,

For similar complex mixtures: tissue extracts research abstracts see: complex mixtures: tissue extracts research

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[The modulation of pilose antler extract (PAE) on the proliferation of rat osteogenic cells UMR-106] Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazh

VOLUME: 29

Page Numbers: 74-7

Journal Abbreviation: Zhongguo Zhong Yao Za Zhi

ISSN: 1001-5302

DAY: 6

MONTH: Jan

YEAR: 2004

[The modulation of pilose antler extract (PAE) on the proliferation of rat osteogenic cells UMR-106] Information

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LANGUAGE: chi

NlmUniqueID: 8913656

[The modulation of pilose antler extract (PAE) on the proliferation of rat osteogenic cells UMR-106] Keywords Mesh Terms:

KEYWORDS: Tissue Extracts

MESH TERMS: pharmacology

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Substance Name: Tissue Extracts

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Grant and Affiliation Information for [The modulation of pilose antler extract (PAE) on the proliferation of rat osteogenic cells UMR-106]

AFFILIATION: Institute of Biotechnology, Fuzhou University, Fuzhou 350002, China.

Country: China

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MEDLINETA: Zhongguo Zhong Yao Za Zhi

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