The metabolism of salicylazosulphapyridine in ulcerative colitis. I. The relationship between metabolites and the response to treatment in inpatients.

The metabolism of salicylazosulphapyridine in ulcerative colitis. I. The relationship between metabolites and the response to treatment in inpatients. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

The metabolism of salicylazosulphapyridine in ulcerative colitis. I. The relationship between metabolites and the response to treatment in inpatients. Abstract Text:

The metabolism of salicylazosulphapyridine was studied in 16 patients with ulcerative colitis admitted to hospital. The acetylator phenotype was determined on admission. The mean serum concentration (mug/ml) (at steady state eight +/- two days in patients responding to treatment) of SASP, total SP, and 5-ASA were 18.7 +/- 12.8; 53.7 +/- 23.1; and 1 +/- 0.9 for slow acetylators and 17.6 +/- 7.1; 31 +/- 9.0 and 1 +/- 0.9 for fast acetylators respectively. Twenty-four hour urinary excretion of SASP, total SP, and 5-ASA were 4.6% +/- 3.1; 52% +/- 9.6 and 22.3 +/- 6.7% of the administered dose respectively.Serum total SP concentration of 20 to 50 mug/ml appeared to coincide with clinical improvement in the absence of any side effects related to salicylazosulphapyridine. No such relationship could be shown with serum SASP, individual metabolites, or 5-aminosalicyclic acid.

The metabolism of salicylazosulphapyridine in ulcerative colitis. I. The relationship between metabolites and the response to treatment in inpatients. Publishing Authors By Initials

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

The metabolism of salicylazosulphapyridine in ulcerative colitis. I. The relationship between metabolites and the response to treatment in inpatients. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Gut

VOLUME: 14

Page Numbers: 631-41

Journal Abbreviation: Gut

ISSN: 0017-5749

DAY: 4

MONTH: Aug

YEAR: 1973

The metabolism of salicylazosulphapyridine in ulcerative colitis. I. The relationship between metabolites and the response to treatment in inpatients. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 2985108

The metabolism of salicylazosulphapyridine in ulcerative colitis. I. The relationship between metabolites and the response to treatment in inpatients. Keywords Mesh Terms:

KEYWORDS: Tablets, Enteric-Coated

MESH TERMS: metabolism

Chemical & Substance for Abstract: The metabolism of salicylazosulphapyridine in ulcerative colitis. I. The relationship between metabolites and the response to treatment in inpatients. Information

Substance Name: Adrenocorticotropic Hormone

Registry Number: 9002-60-2

Grant and Affiliation Information for The metabolism of salicylazosulphapyridine in ulcerative colitis. I. The relationship between metabolites and the response to treatment in inpatients.

AFFILIATION:

Country: ENGLAND

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Gut

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

The metabolism of salicylazosulphapyridine in ulcerative colitis I The relationship between metabolites and the response to treatment in inpatients Related Publications

• 'ORABASE' IN THE MANAGEMENT OF ABDOMINAL-WALL DIGESTION BY ILEOSTOMY AND FISTULAS.
• A flexible oesophagoscope.
• ANKYLOSING SPONDYLITIS AND CHRONIC INFLAMMATORY DISEASES OF THE INTESTINES.
• Comparative evaluation of water recovery test and fluoroscopic screening in positioning a nasogastric tube during gastric secretory studies.
• EVIDENCE FOR A GASTRIC SECRETAGOGUE IN THE CIRCULATION AND GASTRIC JUICE OF PATIENTS WITH ZOLLINGER-ELLISON SYNDROME.
• Experiences with a rat bio-assay in the diagnosis of the Zollinger-Ellison syndrome.
• Factors influencing duodenal trypsin levels following a standard test meal as a test of pancreatic function.
• Faecal stasis and diverticular disease in ulcerative colitis.
• Milestones in the evolution of endoscopy: a short history.
• Nutritional neuropathy in prisoners-of-war repatriated from Hong-Kong; a follow-up.
• Recurrent aphthous ulceration and jejunal biopsy.
• SMOKING DETERRENT STUDY: A REPORT FROM THE RESEARCH COMMITTEE OF THE BRITISH TUBERCULOSIS ASSOCIATION.
• Studies of uropepsinogen excretion in gastrointestinal disorders.
• The effect of corticotrophin and corticosteroids on the external secretion of the pancreas in dogs.
• The management of recurrent aphthous stomatitis.
• The metabolism of salicylazosulphapyridine in ulcerative colitis. I. The relationship between metabolites and the response to treatment in inpatients.