The metabolic syndrome is associated with reduced risk of prostate cancer.

The metabolic syndrome is associated with reduced risk of prostate cancer. Research Abstract Details 

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The metabolic syndrome is associated with reduced risk of prostate cancer. Abstract Text:

Aaron J Tande,Elizabeth A Platz,Aaron R Folsom,

Diabetes is associated with reduced risk of prostate cancer, but whether the metabolic syndrome is associated with prostate cancer is not established. The authors assessed this association in the Atherosclerosis Risk in Communities (ARIC) Study, comprising 6,429 men in four US communities initially with no history of cancer and aged 45-64 years. Metabolic syndrome and other risk factors were assessed in 1987-1989. Follow-up for prostate cancer incidence (n = 385 through 2000) was accomplished through cancer registry and hospital linkage. At baseline, 1,871 men (29.5%) had the metabolic syndrome. After the authors adjusted for other risk factors, men with the metabolic syndrome (> or =3 components) were significantly less likely to develop prostate cancer (relative risk = 0.77, 95% confidence interval: 0.60, 0.98) than men without the metabolic syndrome. Diabetes was negatively associated with prostate cancer, although the confidence interval included 1 (relative risk = 0.73, 95% confidence interval: 0.51, 1.05). When diabetic participants were excluded, the inverse association between metabolic syndrome and prostate cancer incidence was slightly strengthened. In this study, the metabolic syndrome was associated with decreased prostate cancer incidence. The authors hypothesize that this finding reflects a decrease in bioavailable (free and albumin-bound) testosterone with the metabolic syndrome and a concomitant reduction in prostate cancer risk.

The metabolic syndrome is associated with reduced risk of prostate cancer. Publishing Authors By Initials

AJ Tande,EA Platz,AR Folsom,

For similar geographic locations: americas: north america: united states research abstracts see: geographic locations: americas: north america: united states research

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The metabolic syndrome is associated with reduced risk of prostate cancer. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: American journal of epidemiology

VOLUME: 164

Page Numbers: 1094-102

Journal Abbreviation: Am. J. Epidemiol.

ISSN: 0002-9262

DAY: 12

MONTH: 09

YEAR: 2006

The metabolic syndrome is associated with reduced risk of prostate cancer. Information

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LANGUAGE: eng

NlmUniqueID: 7910653

The metabolic syndrome is associated with reduced risk of prostate cancer. Keywords Mesh Terms:

KEYWORDS: United States

MESH TERMS: epidemiology

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Grant and Affiliation Information for The metabolic syndrome is associated with reduced risk of prostate cancer.

AFFILIATION: Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN 55454, USA.

Country: United States

AGENCY: United States NCI

GRANT: R03-CA65473

ACRONYM: CA

MEDLINETA: Am J Epidemiol

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