The medicinal plant goldenseal is a natural LDL-lowering agent with multiple bioactive components and new action mechanisms.

The medicinal plant goldenseal is a natural LDL-lowering agent with multiple bioactive components and new action mechanisms. Research Abstract Details 

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The medicinal plant goldenseal is a natural LDL-lowering agent with multiple bioactive components and new action mechanisms. Abstract Text:

Parveen Abidi,Wei Chen,Fredric B Kraemer,Hai Li,Jingwen Liu,

Our previous studies have identified berberine (BBR), an alkaloid isolated from the Chinese herb huanglian, as a unique cholesterol-lowering drug that upregulates hepatic low density lipoprotein receptor (LDLR) expression through a mechanism of mRNA stabilization. Here, we demonstrate that the root extract of goldenseal, a BBR-containing medicinal plant, is highly effective in upregulation of liver LDLR expression in HepG2 cells and in reducing plasma cholesterol and low density lipoprotein cholesterol (LDL-c) in hyperlipidemic hamsters, with greater activities than the pure compound BBR. By conducting bioassay-driven semipurifications, we demonstrate that the higher potency of goldenseal is achieved through concerted actions of multiple bioactive compounds in addition to BBR. We identify canadine (CND) and two other constituents of goldenseal as new upregulators of LDLR expression. We further show that the activity of BBR on LDLR expression is attenuated by multiple drug resistance-1 (MDR1)-mediated efflux from liver cells, whereas CND is resistant to MDR1. This finding defines a molecular mechanism for the higher activity of CND than BBR. We also provide substantial evidence to show that goldenseal contains natural MDR1 antagonist(s) that accentuate the upregulatory effect of BBR on LDLR mRNA expression. These new findings identify goldenseal as a natural LDL-c-lowering agent, and our studies provide a molecular basis for the mechanisms of action.

The medicinal plant goldenseal is a natural LDL-lowering agent with multiple bioactive components and new action mechanisms. Publishing Authors By Initials

P Abidi,W Chen,FB Kraemer,H Li,J Liu,

For similar nucleic acids, nucleotides, and nucleosides: antisense elements (genetics): rna, antisense: rna, small interfering research abstracts see: nucleic acids, nucleotides, and nucleosides: antisense elements (genetics): rna, antisense: rna, small interfering research

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The medicinal plant goldenseal is a natural LDL-lowering agent with multiple bioactive components and new action mechanisms. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Journal of lipid research

VOLUME: 47

Page Numbers: 2134-47

Journal Abbreviation: J. Lipid Res.

ISSN: 0022-2275

DAY: 2

MONTH: 08

YEAR: 2006

The medicinal plant goldenseal is a natural LDL-lowering agent with multiple bioactive components and new action mechanisms. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 376606

The medicinal plant goldenseal is a natural LDL-lowering agent with multiple bioactive components and new action mechanisms. Keywords Mesh Terms:

KEYWORDS: RNA, Small Interfering

MESH TERMS: chemistry

Chemical & Substance for Abstract: The medicinal plant goldenseal is a natural LDL-lowering agent with multiple bioactive components and new action mechanisms. Information

Substance Name: Berberine

Registry Number: 2086-83-1

Grant and Affiliation Information for The medicinal plant goldenseal is a natural LDL-lowering agent with multiple bioactive components and new action mechanisms.

AFFILIATION: Department of Veterans Affairs Palo Alto Health Care System, Palo Alto, CA 94304, USA.

Country: United States

AGENCY: United States NCCAM

GRANT: 1R01 AT002543-01A1

ACRONYM: AT

MEDLINETA: J Lipid Res

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