The mechanism of outer membrane penetration by the eubacterial flagellum and implications for spirochete evolution.

The mechanism of outer membrane penetration by the eubacterial flagellum and implications for spirochete evolution. Research Abstract Details 

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The mechanism of outer membrane penetration by the eubacterial flagellum and implications for spirochete evolution. Abstract Text:

The rod component of the bacterial flagellum polymerizes from the inner membrane across the periplasmic space and stops at a length of 25 nm at the outer membrane. Bushing structures, the P- and L-rings, polymerize around the distal rod and form a pore in the outer membrane. The flagellar hook structure is then added to the distal rod growing outside the cell. Hook polymerization stops after the rod-hook structure reaches approximately 80 nm in length. This study describes mutants in the distal rod protein FlgG that fail to terminate rod growth. The mutant FlgG subunits continue to polymerize close to the length of the normal rod-hook structure of 80 nm. These filamentous rod structures have multiple P-rings and fail to form the L-ring pore at the outer membrane. The flagella grow within the periplasm similar to spirochete flagella. This provides a simple method to evolve intracellular flagella as in spirochetes. The mechanism that couples rod growth termination to the ring assembly and outer membrane penetration exemplifies the importance of stopping points in the construction of a complex macromolecular machine that facilitate efficient coupling to the next step in the assembly pathway.

The mechanism of outer membrane penetration by the eubacterial flagellum and implications for spirochete evolution. Publishing Authors By Initials

For similar bacteria: spirochaetales research abstracts see: bacteria: spirochaetales research

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The mechanism of outer membrane penetration by the eubacterial flagellum and implications for spirochete evolution. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Genes & development

VOLUME: 21

Page Numbers: 2326-35

Journal Abbreviation: Genes Dev.

ISSN: 0890-9369

DAY: 30

MONTH: 08

YEAR: 2007

The mechanism of outer membrane penetration by the eubacterial flagellum and implications for spirochete evolution. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8711660

The mechanism of outer membrane penetration by the eubacterial flagellum and implications for spirochete evolution. Keywords Mesh Terms:

KEYWORDS: Spirochaetales

MESH TERMS: physiology

Chemical & Substance for Abstract: The mechanism of outer membrane penetration by the eubacterial flagellum and implications for spirochete evolution. Information

Substance Name: FlgM protein, Bacteria

Registry Number: 142462-45-1

Grant and Affiliation Information for The mechanism of outer membrane penetration by the eubacterial flagellum and implications for spirochete evolution.

AFFILIATION: Department of Biology, University of Utah, Salt Lake City, UT 84112, USA.

Country: United States

AGENCY: United States NIGMS

GRANT: GM56141

ACRONYM: GM

MEDLINETA: Genes Dev

REFSOURCE: Genes Dev. 2007 Sep 15;21(18):2253-7

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