The Marinopyrroles, Antibiotics of an Unprecedented Structure Class from a Marine Streptomyces sp.

The Marinopyrroles, Antibiotics of an Unprecedented Structure Class from a Marine Streptomyces sp. Research Abstract Details 

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The Marinopyrroles, Antibiotics of an Unprecedented Structure Class from a Marine Streptomyces sp. Abstract Text:

Chambers C Hughes,Alejandra Prieto-Davo,Paul R Jensen,William Fenical,

Cultivation of an obligate marine Streptomyces strain has furnished the marinopyrroles A and B, densely halogenated, axially chiral metabolites that contain an uncommon bispyrrole structure. X-ray analysis of marinopyrrole B showed that the natural product exists as an atropo-enantiomer with the M-configuration. Though configurationally stable at room temperature, M-(-)-marinopyrrole A can be racemized at elevated temperatures to yield the non-natural P-(+)-atropo-enantiomer. The marinopyrroles possess potent antibiotic activities against methicillin-resistant Staphylococcus aureus.

The Marinopyrroles, Antibiotics of an Unprecedented Structure Class from a Marine Streptomyces sp. Publishing Authors By Initials

CC Hughes,A Prieto-Davo,PR Jensen,W Fenical,

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The Marinopyrroles, Antibiotics of an Unprecedented Structure Class from a Marine Streptomyces sp. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Organic letters

VOLUME: 10

Page Numbers: 629-31

Journal Abbreviation: Org. Lett.

ISSN: 1523-7060

DAY: 19

MONTH: 01

YEAR: 2008

The Marinopyrroles, Antibiotics of an Unprecedented Structure Class from a Marine Streptomyces sp. Information

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LANGUAGE: eng

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Grant and Affiliation Information for The Marinopyrroles, Antibiotics of an Unprecedented Structure Class from a Marine Streptomyces sp.

AFFILIATION: Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California-San Diego, La Jolla, California 92093-0204.

Country: United States

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MEDLINETA: Org Lett

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