The MAPT H1c risk haplotype is associated with increased expression of tau and especially of 4 repeat containing transcripts.

The MAPT H1c risk haplotype is associated with increased expression of tau and especially of 4 repeat containing transcripts. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

The MAPT H1c risk haplotype is associated with increased expression of tau and especially of 4 repeat containing transcripts. Abstract Text:

Amanda J Myers,Alan M Pittman,Alice S Zhao,Kristen Rohrer,Mona Kaleem,Lauren Marlowe,Andrew Lees,Doris Leung,Ian G McKeith,Robert H Perry,Chris M Morris,John Q Trojanowski,Christopher Clark,Jason Karlawish,Steve Arnold,Mark S Forman,Vivianna Van Deerlin,Rohan de Silva,John Hardy,

Previously we have shown that the H1c haplotype on the background of the H1 clade of haplotypes at the MAPT locus is associated with increased risk for progressive supranuclear palsy (PSP), corticobasal degeneration (CBD) and Alzheimer's disease (AD). Here we replicated the association with AD in an additional autopsy confirmed series. We show that this haplotype increases both the expression of total MAPT transcript as well as specifically increasing the proportion of 4 microtubule binding repeat containing transcripts. We discuss these findings both in terms of the problems facing the dissection of the etiologies of complex traits and the pathogenesis of the tauopathies.

The MAPT H1c risk haplotype is associated with increased expression of tau and especially of 4 repeat containing transcripts. Publishing Authors By Initials

AJ Myers,AM Pittman,AS Zhao,K Rohrer,M Kaleem,L Marlowe,A Lees,D Leung,IG McKeith,RH Perry,CM Morris,JQ Trojanowski,C Clark,J Karlawish,S Arnold,MS Forman,V Van Deerlin,R de Silva,J Hardy,

For similar microtubule-associated proteins: tau proteins research abstracts see: microtubule-associated proteins: tau proteins research

PUBMED ID PMID:

MEDLINE DATE:

The MAPT H1c risk haplotype is associated with increased expression of tau and especially of 4 repeat containing transcripts. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Neurobiology of disease

VOLUME: 25

Page Numbers: 561-70

Journal Abbreviation: Neurobiol. Dis.

ISSN: 0969-9961

DAY: 15

MONTH: 12

YEAR: 2006

The MAPT H1c risk haplotype is associated with increased expression of tau and especially of 4 repeat containing transcripts. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9500169

The MAPT H1c risk haplotype is associated with increased expression of tau and especially of 4 repeat containing transcripts. Keywords Mesh Terms:

KEYWORDS: tau Proteins

MESH TERMS: genetics

Chemical & Substance for Abstract: The MAPT H1c risk haplotype is associated with increased expression of tau and especially of 4 repeat containing transcripts. Information

Substance Name: tau Proteins

Registry Number: 0

Grant and Affiliation Information for The MAPT H1c risk haplotype is associated with increased expression of tau and especially of 4 repeat containing transcripts.

AFFILIATION: Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, 35 Convent Drive, Bethesda, MD 20892-3707, USA.

Country: United States

AGENCY: United States NIA

GRANT: P50-AG08671

ACRONYM: AG

MEDLINETA: Neurobiol Dis

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

The MAPT H1c risk haplotype is associated with increased expression of tau and especially of 4 repeat containing transcripts Related Publications

• A single-amino-acid substitution in the P2 domain of VP1 of murine norovirus is sufficient for escape from antibody neutralization.
• ABCA1 polymorphisms and Alzheimer's disease.
• Abnormal preantral folliculogenesis in polycystic ovaries is associated with increased granulosa cell division.
• Anterior cruciate ligament biology and its relationship to injury forces.
• Autoreactive B-1 B cells: Constraints on natural autoantibody B cell antigen receptors.
• B-1 B cells: development, selection, natural autoantibody and leukemia.
• Biphasic effects of postnatal exposure to diethylhexylphthalate on the timing of puberty in male rats.
• Breast cancer metastasis to bone: evaluation of bioluminescent imaging and microSPECT/CT for detecting bone metastasis in immunodeficient mice.
• Contributions of industry to parenteral nutrition.
• Correlation of an FE Model of the Human Head with Local Brain Motion--Consequences for Injury Prediction.
• Development of a cryopreservation protocol for Leydig cells.
• Encountering competitors reduces clutch size and increases offspring size in a parasitoid with female-female fighting.
• Giant prostatic utricle associated with proximal hypospadias: repair by mucosa divesting and muscular tunnel obliteration.
• Intravascular neutrophil activation due to carbon monoxide poisoning.
• Local planar gradients with order-of-magnitude strength and speed advantage.
• Measuring the impact of hepatitis A virus in Chinese cities: a life table approach.
• MedStar health vendor access program: one system's story.
• Respiratory tract infection with Mycoplasma pneumoniae in interleukin-12 knockout mice results in improved bacterial clearance and reduced pulmonary inflammation.
• Speed of lexical decision correlates with diffusion anisotropy in left parietal and frontal white matter: evidence from diffusion tensor imaging.
• Student-driven approach to addressing classroom disturbances suggested.
• Systemic cytokine profile in children with community-acquired pneumonia.
• Testosterone production in mice lacking inducible nitric oxide synthase expression is sensitive to restraint stress.
• The MAPT H1c risk haplotype is associated with increased expression of tau and especially of 4 repeat containing transcripts.
• The effect of different carbohydrate intakes on body weight and nitrogen balance during nasogastric feeding after faciomaxillary surgery.
• The metabolic syndrome: A high-risk state for cancer?
• The stability of ascorbic acid in TPN mixtures stored in a multilayered bag.
• Zinc-binding domain of rotavirus NSP1 is required for proteasome-dependent degradation of IRF3 and autoregulatory NSP1 stability.
• [Double localization of an osteoid osteoma of the ankle: percutaneous treatment by CT-guided drilling]
• [Gender vulnerability for parenthood among male adolescents]
• [Relationship between phthalates and testicular dysgenesis syndrome]