The management of patients with severe malaria.

The management of patients with severe malaria. Research Abstract Details 

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The management of patients with severe malaria. Abstract Text:

Nicholas Day,Arjen M Dondorp,

Severe malaria is a global problem, claiming at least 1 million lives annually. Few adequately powered clinical studies have been directed at improving the management of severe malaria over the years, but this situation is slowly changing. The antimalarial treatment of severe disease is being transformed by the development and deployment of the water-soluble artemisinin derivative artesunate. Parenteral artesunate is now the treatment of choice in low-transmission areas and in the 2nd and 3rd trimesters of pregnancy, and research is underway into whether it should replace quinine as the treatment of choice in African children. Development of good manufacturing practice (GMP) formulations should make parenteral artesunate more widely available in the near future. The development of artesunate suppositories offers another exciting prospect, the ability to treat patients with severe disease in remote rural settings, delaying the evolution of disease and buying them time to reach a health care facility. No adjunctive therapy has been shown to improve the outcome of severe malaria, but most studies have been underpowered. Future trials of interventions shown to be promising in pilot studies should be large and adequately powered. This will require multi-center designs and necessitate close collaboration between groups, as well as agreement on the research agenda. We suggest a list of candidate interventions for debate.

The management of patients with severe malaria. Publishing Authors By Initials

N Day,AM Dondorp,

For similar parasitic diseases: pregnancy complications, parasitic research abstracts see: parasitic diseases: pregnancy complications, parasitic research

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The management of patients with severe malaria. Journal Published:

PUBLICATION TYPE: Review

Journal: The American journal of tropical medicine and hygi

VOLUME: 77

Page Numbers: 29-35

Journal Abbreviation: Am. J. Trop. Med. Hyg.

ISSN: 0002-9637

DAY: 4

MONTH: Dec

YEAR: 2007

The management of patients with severe malaria. Information

Number of References: 59

LANGUAGE: eng

NlmUniqueID: 370507

The management of patients with severe malaria. Keywords Mesh Terms:

KEYWORDS: Pregnancy Complications, Parasitic

MESH TERMS: parasitology

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Grant and Affiliation Information for The management of patients with severe malaria.

AFFILIATION: Faculty of Tropical Medicine, Mahidol University, 420/6 Rajvithi Road, Bangkok, Thailand. nickd@tropmedres.ac

Country: United States

AGENCY: United Kingdom Wellcome T

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MEDLINETA: Am J Trop Med Hyg

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