The mammary bud as a skin appendage: unique and shared aspects of development.

The mammary bud as a skin appendage: unique and shared aspects of development. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

The mammary bud as a skin appendage: unique and shared aspects of development. Abstract Text:

Marja L Mikkola,Sarah E Millar,

Like other skin appendages, the embryonic mammary gland develops via extensive epithelial-mesenchymal interactions. Early stages in embryonic mammary development strikingly resemble analogous steps in the development of hair follicles and teeth. In each case the first morphological sign of development is a localized thickening in the surface epithelium that subsequently invaginates to form a mammary, hair follicle or tooth bud. Similar sets of intersecting signaling pathways are involved in patterning the mammary, hair follicle and dental epithelium, directing placode formation, and controlling bud invagination. Despite these similarities, subsequent events in the formation of these appendages are diverse. The mammary bud extends to form a sprout that begins to branch upon contact with the mammary fat pad. Hair follicles also extend into the underlying mesenchyme, but instead of branching, hair follicle epithelium folds around a condensation of dermal cells. In contrast, teeth undergo a more complex folding morphogenesis. Here, we review what is known of the molecular and cellular mechanisms controlling early steps in the development of these organs, attempt to unravel both common themes and unique aspects that can begin to explain the diversity of appendage formation, and discuss human genetic diseases that affect appendage morphogenesis.

The mammary bud as a skin appendage: unique and shared aspects of development. Publishing Authors By Initials

ML Mikkola,SE Millar,

For similar tooth research abstracts see: tooth research

PUBMED ID PMID:

MEDLINE DATE:

The mammary bud as a skin appendage: unique and shared aspects of development. Journal Published:

PUBLICATION TYPE: Review

Journal: Journal of mammary gland biology and neoplasia

VOLUME: 11

Page Numbers: 187-203

Journal Abbreviation:

ISSN: 1083-3021

DAY: 3

MONTH: Oct

YEAR: 2006

The mammary bud as a skin appendage: unique and shared aspects of development. Information

Number of References: 153

LANGUAGE: eng

NlmUniqueID: 9601804

The mammary bud as a skin appendage: unique and shared aspects of development. Keywords Mesh Terms:

KEYWORDS: Tooth

MESH TERMS: growth & development

Chemical & Substance for Abstract: The mammary bud as a skin appendage: unique and shared aspects of development. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for The mammary bud as a skin appendage: unique and shared aspects of development.

AFFILIATION: Developmental Biology Program, Institute of Biotechnology, University of Helsinki, PO Box 56, Viikinkaari 9, Helsinki, 00014, Finland.

Country: United States

AGENCY: United States NIDCR

GRANT: R01-DE015342

ACRONYM: DE

MEDLINETA: J Mammary Gland Biol Neoplasia

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

The mammary bud as a skin appendage: unique and shared aspects of development Related Publications

• A competencies-based mental health training model for health professionals in low and middle income countries.
• A critique of interest-based bargaining.
• AUXILIARY APPARATUS FOR THE AUTOCLAVE.
• Be it enacted.
• Bilateral asymmetry shown by the metachronal waves in protochordate gill slits.
• Circadian Genetics in the Model Higher Plant, Arabidopsis thaliana.
• Communities' views on tackling health inequalities: the case of Ballyeast and Ballywest.
• Conformational dynamics of DNA polymerase probed with a novel fluorescent DNA base analogue.
• Dimerization of the Klenow fragment of Escherichia coli DNA polymerase I is linked to its mode of DNA binding.
• Don't fumble the handoff. Inpatient providers, specialists, and the primary care physician: a medical care delivery system with benefits and complex risks.
• EPILEPSY AND STRABISMUS.
• Evaluation of fuadin therapy in schistosomiasis japonica.
• Foregut atresias and bile duct anomalies: rare, infrequent or common?!
• Free-flow electrophoresis for purification of plant mitochondria by surface charge.
• Genetic analysis reveals functional redundancy and the major target genes of the Arabidopsis miR159 family.
• Identification of domains influencing assembly and ion channel properties in alpha 7 nicotinic receptor and 5-HT3 receptor subunit chimaeras.
• Identification of intra- and intermolecular disulphide bonding in the plant mitochondrial proteome by diagonal gel electrophoresis.
• Ireland's legacy to Sir William Osler, 1849-1919.
• Phospholipase C-eta enzymes as putative protein kinase C and Ca2+ signalling components in neuronal and neuroendocrine tissues.
• Poliomyelitis in Johannesburg.
• Scotland has poverty in its sights.
• Se18 a tale of two colleges: do specialist trainees receive adequate hospital-based training?
• Small scale ampoule production.
• Streptomycin therapy in orthopedic tuberculosis.
• The DISC locus in psychiatric illness.
• The Dam1/DASH complex is required for the retrieval of unclustered kinetochores in fission yeast.
• The egg parasitoid Trissolcus basalis uses n-nonadecane, a cuticular hydrocarbon from its stink bug host Nezara viridula, to discriminate between female and male hosts.
• The mammary bud as a skin appendage: unique and shared aspects of development.
• Wnt/beta-catenin signaling directs multiple stages of tooth morphogenesis.
• Wrist buckle fractures: a survey of current practice patterns and attitudes toward immobilization.