The major vault protein is related to the toxic anion resistance protein (TelA) family.

The major vault protein is related to the toxic anion resistance protein (TelA) family. Research Abstract Details 

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The major vault protein is related to the toxic anion resistance protein (TelA) family. Abstract Text:

Kathy A Suprenant,Nathan Bloom,Jianwen Fang,Gerald Lushington,

Vaults are barrel-shaped ribonucleoprotein particles that are abundant in certain tumors and multidrug resistant cancer cells. Prokaryotic relatives of the major vault protein, MVP, have not been identified. We used sequence analysis and molecular modeling to show that MVP and the toxic anion resistance protein, TelA of Rhodobacter sphaeroides strain 2.4.1, share a novel fold that consists of a three-stranded antiparallel beta-sheet. Because of this strong structural correspondence, we examined whether mammalian cell vaults respond to tellurite treatment. In the presence of the oxyanion tellurite, large vault aggregates, or vaultosomes, appear at the cell periphery in 15 min or less. Vaultosome formation is temperature-dependent, reversible, and occurs in normal human umbilical vein endothelial cells as well as transformed HeLa cervical cancer cells. Vaultosome formation is not restricted to tellurite and occurs in the presence of other toxic oxyanions (selenate, selinite, arsenate, arsenite, vanadate). In addition, vaultosomes form independently from other stress-induced ribonucleoprotein complexes, stress granules and aggresomes. Vaultosome formation is therefore a unique cellular response to an environmental toxin.

The major vault protein is related to the toxic anion resistance protein (TelA) family. Publishing Authors By Initials

KA Suprenant,N Bloom,J Fang,G Lushington,

For similar cells: cellular structures: intracellular space: cytoplasm: cytoplasmic structures: organelles: vault ribonucleoprotein particles research abstracts see: cells: cellular structures: intracellular space: cytoplasm: cytoplasmic structures: organelles: vault ribonucleoprotein particles research

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The major vault protein is related to the toxic anion resistance protein (TelA) family. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: The Journal of experimental biology

VOLUME: 210

Page Numbers: 946-55

Journal Abbreviation: J. Exp. Biol.

ISSN: 0022-0949

DAY: 3

MONTH: Mar

YEAR: 2007

The major vault protein is related to the toxic anion resistance protein (TelA) family. Information

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LANGUAGE: eng

NlmUniqueID: 243705

The major vault protein is related to the toxic anion resistance protein (TelA) family. Keywords Mesh Terms:

KEYWORDS: Vault Ribonucleoprotein Particles

MESH TERMS: metabolism

Chemical & Substance for Abstract: The major vault protein is related to the toxic anion resistance protein (TelA) family. Information

Substance Name: vault poly(ADP-ribose) polymerase

Registry Number: EC 2.4.2.30

Grant and Affiliation Information for The major vault protein is related to the toxic anion resistance protein (TelA) family.

AFFILIATION: Department of Molecular Biosciences, University of Kansas, Lawrence, KS 66045, USA. ksupre@ku.edu

Country: England

AGENCY: United States NCRR

GRANT: P20 RR016475

ACRONYM: RR

MEDLINETA: J Exp Biol

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