The lysine 831 of vascular endothelial growth factor receptor 1 is a novel target of methylation by SMYD3.

The lysine 831 of vascular endothelial growth factor receptor 1 is a novel target of methylation by SMYD3. Research Abstract Details 

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The lysine 831 of vascular endothelial growth factor receptor 1 is a novel target of methylation by SMYD3. Abstract Text:

Masaki Kunizaki,Ryuji Hamamoto,Fabio Pittella Silva,Kiyoshi Yamaguchi,Takeshi Nagayasu,Masabumi Shibuya,Yusuke Nakamura,Yoichi Furukawa,

We previously identified SMYD3 as a histone methyltransferase and showed that its expression was elevated in colorectal, hepatocellular, and breast carcinomas. In the investigation of methyltransferase activity of SMYD3, we have found that vascular endothelial growth factor receptor 1 (VEGFR1) was also methylated by SMYD3. We further identified the methylated residue at VEGFR1 lysine 831, which is located in the kinase domain and is conserved among VEGFR1 orthologues. We also found that the lysine is followed by serine, which is conserved among some of the methylation targets of histone methyltransferases. Furthermore, methylation of VEGFR1 enhanced its kinase activity in cells. These data should be helpful for the profound understanding of the biological role of SMYD3 and regulatory mechanisms of VEGFR1. Additionally our finding may facilitate the development of strategies that may inhibit the progression of cancer cells.

The lysine 831 of vascular endothelial growth factor receptor 1 is a novel target of methylation by SMYD3. Publishing Authors By Initials

M Kunizaki,R Hamamoto,FP Silva,K Yamaguchi,T Nagayasu,M Shibuya,Y Nakamura,Y Furukawa,

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The lysine 831 of vascular endothelial growth factor receptor 1 is a novel target of methylation by SMYD3. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Cancer research

VOLUME: 67

Page Numbers: 10759-65

Journal Abbreviation: Cancer Res.

ISSN: 1538-7445

DAY: 15

MONTH: Nov

YEAR: 2007

The lysine 831 of vascular endothelial growth factor receptor 1 is a novel target of methylation by SMYD3. Information

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LANGUAGE: eng

NlmUniqueID: 2984705

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Grant and Affiliation Information for The lysine 831 of vascular endothelial growth factor receptor 1 is a novel target of methylation by SMYD3.

AFFILIATION: Laboratory of Molecular Medicine, Human Genome Center, The University of Tokyo, Tokyo, Japan.

Country: United States

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MEDLINETA: Cancer Res

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