The lymphovascular embolus of inflammatory breast cancer expresses a stem cell-like phenotype.

The lymphovascular embolus of inflammatory breast cancer expresses a stem cell-like phenotype. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

The lymphovascular embolus of inflammatory breast cancer expresses a stem cell-like phenotype. Abstract Text:

Inflammatory breast carcinoma (IBC) is a particularly lethal form of breast cancer characterized by exaggerated lymphovascular invasion, which is a phenotype recapitulated in our human xenograft MARY-X. MARY-X generated spheroids in vitro that resemble the embryonal blastocyst. Because of the resemblance of the spheroids to the embryonal blastocyst and their resistance to traditional chemotherapy/radiotherapy, we hypothesized that the spheroids expressed a stem cell-like phenotype. MARY-X spheroids expressed embryonal stem cell markers including stellar, rex-1, nestin, H19, and potent transcriptional factors, oct-4, nanog, and sox-2, which are associated with stem cell self-renewal and developmental potential. Most importantly, MARY-X spheroids expressed a cancer stem cell profile characterized by CD44(+)/CD24(-/low), ALDH1, and most uniquely, CD133. A significant percentage of single cells of MARY-X exhibited distinct proliferative and morphogenic potencies in vitro. As few as 100 cells derived from single-cell clonogenic expansion were tumorigenic with recapitulation of the IBC phenotype. Prototype stem cell signaling pathways such as notch3 were active in MARY-X. The stem cell phenotype exhibited by MARY-X also was exhibited by the lymphovascular emboli of human IBC cases independent of their molecular subtype. This stem cell-like phenotype may contribute to the aggressive nature of IBC but also may lend itself to selective targeting.

The lymphovascular embolus of inflammatory breast cancer expresses a stem cell-like phenotype. Publishing Authors By Initials

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

The lymphovascular embolus of inflammatory breast cancer expresses a stem cell-like phenotype. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: The American journal of pathology

VOLUME: 173

Page Numbers: 561-74

Journal Abbreviation: Am. J. Pathol.

ISSN: 1525-2191

DAY: 3

MONTH: 07

YEAR: 2008

The lymphovascular embolus of inflammatory breast cancer expresses a stem cell-like phenotype. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 370502

The lymphovascular embolus of inflammatory breast cancer expresses a stem cell-like phenotype. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: The lymphovascular embolus of inflammatory breast cancer expresses a stem cell-like phenotype. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for The lymphovascular embolus of inflammatory breast cancer expresses a stem cell-like phenotype.

AFFILIATION: Department of Pathology, The Ohio State University College of Medicine, 129 Hamilton Hall, 1645 Neil Ave., Columbus, OH 43210-1218, USA.

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Am J Pathol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

The lymphovascular embolus of inflammatory breast cancer expresses a stem cell-like phenotype Related Publications

• Acquired localized hypertrichosis.
• An evaluation of well child clinics in the province of Manitoba.
• Basal cell epithelioma of the palm.
• Clinical application of somatosensory amplification in psychosomatic medicine.
• Construction and architecture of a small animal clinic.
• Does science education need the history of science?
• Health supervision of young children in Manitoba.
• Lichen striatus with nail dystrophy.
• MUC2 is a molecular marker for pseudomyxoma peritonei.
• Melanoacanthoma of the lip.
• Motion of a DNA sliding clamp observed by single molecule fluorescence spectroscopy.
• Multicenter trial analysis. Fluocinonide and betamethasone gel in psoriasis.
• Pseudo-ophiasis and sickle cell anemia.
• Pseudomyxoma peritonei is a disease of MUC2-expressing goblet cells.
• RECENT ADVANCES IN DERMATOLOGY.
• Restoration of the thumb by transplantation, plastic repair, and prosthesis.
• Rickets: Canada: 1968.
• Terrorism, trauma, and mass casualty triage: how might we solve the latest mind-body problem?
• The lymphovascular embolus of inflammatory breast cancer expresses a stem cell-like phenotype.
• Ulcerative sarcoidosis.
• Urticaria and angioedema.
• What affects time to care in emergency room appendicitis patients?
• [In Process Citation]
• [In Process Citation]
• [In Process Citation]
• [In Process Citation]