The lubricating ability of biomembrane models with dipalmitoyl phosphatidylcholine and gamma-globulin.

The lubricating ability of biomembrane models with dipalmitoyl phosphatidylcholine and gamma-globulin. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

The lubricating ability of biomembrane models with dipalmitoyl phosphatidylcholine and gamma-globulin. Abstract Text:

H Higaki,T Murakami,Y Nakanishi,H Miura,T Mawatari,Y Iwamoto,

Two kinds of friction tests were conducted to investigate the lubricating effect of the injection of amphiphilies on the osteoarthritic joint. The effects of the addition of L alpha-dipalmitoyl phosphatidyl-choline (L alpha-DPPC) riposomes and gamma-globulin in a saline solution of sodium hyaluronate (HA) were evaluated through pendulum friction tests. The frictional characteristics of pig shoulder joints were confirmed to depend on the viscosity of the lubricants only in the physiologically low load condition and in the condition immediately after loading. Detergent (polyoxyethylene p-t-octylphenyl ether) was successfully used to remove adsorbed films from the articular surfaces. The friction coefficient of natural synovial joints was significantly increased in a mode of mixed lubrication with the HA solution of 0.2 g/dl by the treatment of the surface with the detergent. The addition of L alpha-DPPC riposomes or gamma-globulin significantly improved the boundary lubricating ability of the articular surfaces treated with the detergent, depending on the quantity of those additives. It appears that the L alpha-DPPC riposomes and gamma-globulin can form protective films on the articular surfaces like a biomembrane. Moreover, the reciprocating frictional behaviour in sliding pairs of pig articular cartilages and glass plates was studied in order to elucidate the tribological role of those constituents in the boundary lubricating film on the articular surface. Pig synovial fluid and water solutions of HA were used as lubricants. The synovial fluid had superior lubricating ability compared to the HA solution of equivalent viscosity under a physiologically high load condition. This fact seems to be responsible for the boundary lubricating ability of constituents other than hyaluronic acid. Langmuir-Blodgett (LB) films of L alpha-DPPC on the glass plate were kept at a low and stable friction coefficient, depending on the number of film layers. In conditions of mixed films with L alpha-DPPC and gamma-globulin, the frictional behaviour was improved by increasing the quantity of gamma-globulin. A model is proposed in which the effective adsorbed films are composed of proteins, phospholipids and other conjugated constituents on the articular surfaces to be accurate in describing the boundary lubricating mechanism. The mechanism is controlled by hydrophobic groups in those amphiphilies.

The lubricating ability of biomembrane models with dipalmitoyl phosphatidylcholine and gamma-globulin. Publishing Authors By Initials

H Higaki,T Murakami,Y Nakanishi,H Miura,T Mawatari,Y Iwamoto,

For similar proteins: blood proteins: immunoproteins: immunoglobulins: gamma-globulins research abstracts see: proteins: blood proteins: immunoproteins: immunoglobulins: gamma-globulins research

PUBMED ID PMID:

MEDLINE DATE:

The lubricating ability of biomembrane models with dipalmitoyl phosphatidylcholine and gamma-globulin. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Proceedings of the Institution of Mechanical Engin

VOLUME: 212

Page Numbers: 337-46

Journal Abbreviation:

ISSN: 0954-4119

DAY: 21

MONTH: 02

YEAR: 1998

The lubricating ability of biomembrane models with dipalmitoyl phosphatidylcholine and gamma-globulin. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8908934

The lubricating ability of biomembrane models with dipalmitoyl phosphatidylcholine and gamma-globulin. Keywords Mesh Terms:

KEYWORDS: gamma-Globulins

MESH TERMS: therapeutic use

Chemical & Substance for Abstract: The lubricating ability of biomembrane models with dipalmitoyl phosphatidylcholine and gamma-globulin. Information

Substance Name: Hyaluronic Acid

Registry Number: 9004-61-9

Grant and Affiliation Information for The lubricating ability of biomembrane models with dipalmitoyl phosphatidylcholine and gamma-globulin.

AFFILIATION: Department of Intelligent Machinery and Systems, Faculty of Engineering, Kyushu University, Hakozaki Fukuoka, Japan.

Country: ENGLAND

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Proc Inst Mech Eng [H]

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

The lubricating ability of biomembrane models with dipalmitoyl phosphatidylcholine and gamma-globulin Related Publications

• A study to determine the effects of food and multiple dosing on the pharmacokinetics of vorinostat given orally to patients with advanced cancer.
• Age-related differences in muscle activity, stride frequency and heart rate response during walking in water.
• Applicability of Nanotrap Sg as a semen detection kit before male-specific DNA profiling in sexual assaults.
• Comparative analysis of interindividual variations in the seminal plasma proteome of fertile men with identification of potential markers for azoospermia in infertile patients.
• Computed tomography-based navigation to determine the socket location in total hip arthroplasty of an osteoarthritis hip with a large leg length discrepancy due to severe acetabular dysplasia.
• Deep gray matter hyperperfusion with occipital hypoperfusion in dementia with Lewy bodies.
• Desmoplastic fibroblastoma (collagenous fibroma) with a specific breakpoint of 11q12.
• Detection of luminal contour using fuzzy clustering and mathematical morphology in intravascular ultrasound images.
• Difference in segmental lean and fat mass components between pre- and postmenopausal women.
• Etiology of decreased gastric nitric oxide in the critically ill.
• Exercise training after maturation induces neuroplastic changes in cardiorespiratory and locomotor centers of the brain: 1609: board #99 may 30 3:30 PM - 5:00 PM.
• Extremely low birth weight infants are at high risk for auditory neuropathy.
• Factors associated with pain and functional limitation in Japanese male patients with knee osteoarthritis.
• Hedgehog proteins stimulate chondrogenic cell differentiation and cartilage formation.
• Impact of neonatal hypothyroidism on reproduction in the male hamster, Mesocricetus auratus.
• Intramuscular bone induction by the simultaneous administration of recombinant human bone morphogenetic protein 2 and bisphosphonate for autobone graft.
• Intranuclear localization and isoform-dependent translocation of 14-3-3 proteins in human brain with infarction.
• Metastasis to the gluteus maximus muscle from renal cell carcinoma with special emphasis on MRI features.
• Molecular basis of basal cell carcinogenesis in the atomic-bomb survivor population: p53 and PTCH gene alterations.
• Nilvadipine prevents cognitive decline of patients with mild cognitive impairment.
• Photochange in pore diameters of azobenzene-planted mesoporous silica materials.
• Plasma brain natriuretic peptide levels indicating thromboembolism in very elderly patients with non-valvular atrial fibrillation.
• Salicylate-based analgesic balm attenuates pressor responses from skeletal muscle.
• Structures of sugar chains of the subunits of an alpha-amylase inhibitor from Phaseolus vulgaris white kidney beans.
• Studies on the uronic acid-containing glycoproteins of Fusarium sp. M7-1: IV. Isolation and identification of four novel oligosaccharide units derived from the acidic polysaccharide chain.
• Survey of dietary habits in obese patients with type 2 diabetes treated with either OHA or insulin injections in Japan.
• [Diagnosis and treatment using double balloon endoscopy]
• [Efficacy of S-1 combined with weekly Paclitaxel for gastric cancer with cancerous ascites]
• [Lacunar infarcts in the elderly with special reference to their historical aspects]
• [Osteosarcoma and pain]