The long-term efficacy of Helicobacter pylori eradication therapy in patients with idiopathic thrombocytopenic purpura.

The long-term efficacy of Helicobacter pylori eradication therapy in patients with idiopathic thrombocytopenic purpura. Research Abstract Details 

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The long-term efficacy of Helicobacter pylori eradication therapy in patients with idiopathic thrombocytopenic purpura. Abstract Text:

Masaaki Satake,Jun Nishikawa,Yuki Fukagawa,Keiko Akashi,Takeshi Okamoto,Tomoharu Yoshida,Atsuyoshi Hirano,Noboru Maetani,Youzou Iida,Isao Sakaida,Masaaki Satake,Jun Nishikawa,Yuki Fukagawa,Keiko Akashi,Takeshi Okamoto,Tomoharu Yoshida,Atsuyoshi Hirano,Noboru Maetani,Youzou Iida,Isao Sakaida,Masaaki Satake,Jun Nishikawa,Yuki Fukagawa,Keiko Akashi,Takeshi Okamoto,Tomoharu Yoshida,Atsuyoshi Hirano,Noboru Maetani,Youzou Iida,Isao Sakaida,

Background and Aim: A beneficial effect of Helicobacter pylori (H. pylori) eradication in patients with H. pylori-positive idiopathic thrombocytopenic purpura (ITP) has been reported by several investigators; however, it was not clear whether the recovered platelet count after H. pylori eradication was maintained for a long period. Method: Thirty-eight ITP patients who were examined for H. pylori infection were assessed. H. pylori-positive patients received a standard antibiotic therapy for H. pylori eradication. We investigated the long-term effect of H. pylori eradication on platelet recovery in patients with H. pylori-positive ITP. Results: Of the 38 ITP patients, 26 (68.4%) were positive for H. pylori. The response rate of platelet recovery was 56.5% (13/23 patients). Twelve patients showed complete response (CR) and one showed partial response (PR). The mean platelet counts 6 months after eradication significantly increased from 31 x 10(9)/L to 129 x 10(9)/L in 23 H. pylori-eradicated patients (P < 0.001). The median platelet counts of responders 1, 2, 3, and 4 years after eradication were 168 x 10(9)/L (n = 10), 193 x 10(9)/L (n = 9), 168 x 10(9)/L (n = 7), and 243 x 10(9)/L (n = 4) after a mean follow-up of 25.8 months. Conclusion: Eradication therapy for H. pylori-positive patients with ITP was effective and a favorable effect was maintained for long periods.

The long-term efficacy of Helicobacter pylori eradication therapy in patients with idiopathic thrombocytopenic purpura. Publishing Authors By Initials

M Satake,J Nishikawa,Y Fukagawa,K Akashi,T Okamoto,T Yoshida,A Hirano,N Maetani,Y Iida,I Sakaida,M Satake,J Nishikawa,Y Fukagawa,K Akashi,T Okamoto,T Yoshida,A Hirano,N Maetani,Y Iida,I Sakaida,M Satake,J Nishikawa,Y Fukagawa,K Akashi,T Okamoto,T Yoshida,A Hirano,N Maetani,Y Iida,I Sakaida,

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The long-term efficacy of Helicobacter pylori eradication therapy in patients with idiopathic thrombocytopenic purpura. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of gastroenterology and hepatology

VOLUME: 22

Page Numbers: 2233-7

Journal Abbreviation: J. Gastroenterol. Hepatol.

ISSN: 0815-9319

DAY: 7

MONTH: 06

YEAR: 2007

The long-term efficacy of Helicobacter pylori eradication therapy in patients with idiopathic thrombocytopenic purpura. Information

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LANGUAGE: eng

NlmUniqueID: 8607909

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AFFILIATION: Department of Gastroenterology and Hepatology, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan.

Country: Australia

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MEDLINETA: J Gastroenterol Hepatol

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