The lipid whisker model of the structure of oxidized cell membranes.

The lipid whisker model of the structure of oxidized cell membranes. Research Abstract Details 

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The lipid whisker model of the structure of oxidized cell membranes. Abstract Text:

Michael E Greenberg,Xin-Min Li,Bogdan G Gugiu,Xiaodong Gu,Jun Qin,Robert G Salomon,Stanley L Hazen,Michael E Greenberg,Xin-Min Li,Bogdan G Gugiu,Xiaodong Gu,Jun Qin,Robert G Salomon,Stanley L Hazen,Michael E Greenberg,Xin-Min Li,Bogdan G Gugiu,Xiaodong Gu,Jun Qin,Robert G Salomon,Stanley L Hazen,

An essential feature of the innate immune system is maintaining cellular homeostasis by identifying and removing senescent and apoptotic cells and modified lipoproteins. Identification is achieved through the recognition of molecular patterns, including structurally distinct oxidized phospholipids, on target cells by macrophage receptors. Both the structural nature of the molecular patterns recognized and their orientation within membranes has remained elusive. We recently described the membrane conformation of an endogenous oxidized phospholipid ligand for macrophage scavenger receptor CD36, where the truncated oxidized sn-2 fatty acid moiety protrudes into the aqueous phase, rendering it accessible for recognition. Herein we examine the generality of this conformational motif for peroxidized glycerophospholipids within membranes. Our data reveal that the addition of a polar oxygen atom on numerous peroxidized fatty acids reorients the acyl chain, whereby it no longer remains buried within the membrane interior but rather protrudes into the aqueous compartment. Moreover, we show that neither a conformational change in the head group relative to the membrane surface nor the presence of a polar head group is essential for CD36 recognition of free oxidized phospholipid ligands within membranes. Rather, our results suggest the following global phenomenon. As cellular membranes undergo lipid peroxidation, such as during senescence or apoptosis, previously hydrophobic portions of fatty acids will move from the interior of the lipid bilayer to the aqueous exterior. This enables physical contact between pattern recognition receptor and molecular pattern ligand. Cell membranes thus "grow whiskers" as phospholipids undergo peroxidation, and many of their oxidized fatty acids protrude at the surface.

The lipid whisker model of the structure of oxidized cell membranes. Publishing Authors By Initials

ME Greenberg,XM Li,BG Gugiu,X Gu,J Qin,RG Salomon,SL Hazen,ME Greenberg,XM Li,BG Gugiu,X Gu,J Qin,RG Salomon,SL Hazen,ME Greenberg,XM Li,BG Gugiu,X Gu,J Qin,RG Salomon,SL Hazen,

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The lipid whisker model of the structure of oxidized cell membranes. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: The Journal of biological chemistry

VOLUME: 283

Page Numbers: 2385-96

Journal Abbreviation: J. Biol. Chem.

ISSN: 0021-9258

DAY: 28

MONTH: 11

YEAR: 2007

The lipid whisker model of the structure of oxidized cell membranes. Information

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LANGUAGE: eng

NlmUniqueID: 2985121

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Grant and Affiliation Information for The lipid whisker model of the structure of oxidized cell membranes.

AFFILIATION: Departments of Cell Biology, Molecular Cardiology, and Cardiovascular Medicine.

Country: United States

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MEDLINETA: J Biol Chem

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