The Kruppel-associated Box Repressor Domain Can Trigger de Novo Promoter Methylation during Mouse Early Embryogenesis.

The Kruppel-associated Box Repressor Domain Can Trigger de Novo Promoter Methylation during Mouse Early Embryogenesis. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

The Kruppel-associated Box Repressor Domain Can Trigger de Novo Promoter Methylation during Mouse Early Embryogenesis. Abstract Text:

Maciej Wiznerowicz,Johan Jakobsson,Jolanta Szulc,Shunyao Liao,Alexandra Quazzola,Friedrich Beermann,Patrick Aebischer,Didier Trono,Maciej Wiznerowicz,Johan Jakobsson,Jolanta Szulc,Shunyao Liao,Alexandra Quazzola,Friedrich Beermann,Patrick Aebischer,Didier Trono,Maciej Wiznerowicz,Johan Jakobsson,Jolanta Szulc,Shunyao Liao,Alexandra Quazzola,Friedrich Beermann,Patrick Aebischer,Didier Trono,

The Krüppel-associated box (KRAB) domain is a transcriptional repression module responsible for the DNA binding-dependent gene silencing activity of hundreds of vertebrate zinc finger proteins. We previously exploited KRAB-mediated repression within the context of a tet repressor-KRAB fusion protein and of lentiviral vectors to create a method of external gene control. We demonstrated that with this system transcriptional silencing was fully reversible in cell culture as well as in vivo. Here we reveal that, in sharp contrast, KRAB-mediated repression results in irreversible gene silencing through promoter DNA methylation if it acts during the first few days of mouse development.

The Kruppel-associated Box Repressor Domain Can Trigger de Novo Promoter Methylation during Mouse Early Embryogenesis. Publishing Authors By Initials

M Wiznerowicz,J Jakobsson,J Szulc,S Liao,A Quazzola,F Beermann,P Aebischer,D Trono,M Wiznerowicz,J Jakobsson,J Szulc,S Liao,A Quazzola,F Beermann,P Aebischer,D Trono,M Wiznerowicz,J Jakobsson,J Szulc,S Liao,A Quazzola,F Beermann,P Aebischer,D Trono,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

The Kruppel-associated Box Repressor Domain Can Trigger de Novo Promoter Methylation during Mouse Early Embryogenesis. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: The Journal of biological chemistry

VOLUME: 282

Page Numbers: 34535-41

Journal Abbreviation: J. Biol. Chem.

ISSN: 0021-9258

DAY: 24

MONTH: 09

YEAR: 2007

The Kruppel-associated Box Repressor Domain Can Trigger de Novo Promoter Methylation during Mouse Early Embryogenesis. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 2985121

The Kruppel-associated Box Repressor Domain Can Trigger de Novo Promoter Methylation during Mouse Early Embryogenesis. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: The Kruppel-associated Box Repressor Domain Can Trigger de Novo Promoter Methylation during Mouse Early Embryogenesis. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for The Kruppel-associated Box Repressor Domain Can Trigger de Novo Promoter Methylation during Mouse Early Embryogenesis.

AFFILIATION: School of Life Sciences, "Frontiers in Genetics" National Center for Competence in Research, and Swiss Institute for Experimental Cancer Research, Ecole Polytechnique Fédérale de Lausanne, CH-1015 Lausanne, Switzerland.

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: J Biol Chem

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

The Kruppel-associated Box Repressor Domain Can Trigger de Novo Promoter Methylation during Mouse Early Embryogenesis Related Publications

• A new optical platform for biosensing based on fluorescence anisotropy.
• APOBEC3-independent interferon-induced viral clearance in hepatitis B virus transgenic mice.
• Characterization of APOBEC3G binding to 7SL RNA.
• Genotypic features of lentivirus transgenic mice.
• Interfering residues narrow the spectrum of MLV restriction by human TRIM5alpha.
• Production and titration of lentiviral vectors.
• Production and titration of lentiviral vectors.
• The Kruppel-associated Box Repressor Domain Can Trigger de Novo Promoter Methylation during Mouse Early Embryogenesis.
• The Nef protein of human immunodeficiency virus type 1 enhances serine phosphorylation of the viral matrix.
• Western blot assay using recombinant p26 antigen for detection of equine infectious anemia virus-specific antibodies.