The known unknowns of antigen processing and presentation.

The known unknowns of antigen processing and presentation. Research Abstract Details 

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The known unknowns of antigen processing and presentation. Abstract Text:

The principal components of both MHC class I and class II antigen processing and presentation pathways are well known. In dendritic cells, these pathways are tightly regulated by Toll-like-receptor signalling and include features, such as cross-presentation, that are not seen in other cell types. However, the exact mechanisms involved in the subcellular trafficking of antigens remain poorly understood and in some cases are controversial. Recent data suggest that diverse cellular machineries, including autophagy, participate in antigen processing and presentation, although their relative contributions remain to be fully elucidated. Here, we highlight some emerging themes of antigen processing and presentation that we think merit further attention.

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The known unknowns of antigen processing and presentation. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Nature reviews. Immunology

VOLUME: 8

Page Numbers: 607-18

Journal Abbreviation: Nat. Rev. Immunol.

ISSN: 1474-1741

DAY: 25

MONTH: Aug

YEAR: 2008

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LANGUAGE: eng

NlmUniqueID: 101124169

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Grant and Affiliation Information for The known unknowns of antigen processing and presentation.

AFFILIATION: Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA.

Country: England

AGENCY: United States NIAID

GRANT: R37 AI33456

ACRONYM: AI

MEDLINETA: Nat Rev Immunol

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