The kinin antagonist hoe 140 reduces acute paw oedema in rats caused by carrageenan, bradykinin and kaolin.

The kinin antagonist hoe 140 reduces acute paw oedema in rats caused by carrageenan, bradykinin and kaolin. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

The kinin antagonist hoe 140 reduces acute paw oedema in rats caused by carrageenan, bradykinin and kaolin. Abstract Text:

J N Sharma,A P Yusof,K J Wirth,

The present study aimed to evaluate the effect of Hoe 140, a BK receptor B(2) antagonist, on acute oedema induced by carrageenan, BK and kaolin in male Wistar Kyoto rats. Hoe 140 (0.2 mg/kg and 20 mg/kg) given ip caused significant (p<0.05 and p<0.01) inhibition of carrageenan and BK-induced paw oedema. This suggests that BK is the prime inflammatory mediator of carrageenan oedema, and that it is also a specific blocker of oedema caused by BK. Furthermore, Hoe 140 was found to be less effective in reducing kaolin-induced oedema in rats. This might reflect that BK is not a prime inflammatory mediator of kaolin-induced oedema. The possible significance of these findings is discussed.

The kinin antagonist hoe 140 reduces acute paw oedema in rats caused by carrageenan, bradykinin and kaolin. Publishing Authors By Initials

JN Sharma,AP Yusof,KJ Wirth,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

The kinin antagonist hoe 140 reduces acute paw oedema in rats caused by carrageenan, bradykinin and kaolin. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Inflammopharmacology

VOLUME: 6

Page Numbers: 9-17

Journal Abbreviation:

ISSN: 0925-4692

DAY: 19

MONTH: 07

YEAR: 1998

The kinin antagonist hoe 140 reduces acute paw oedema in rats caused by carrageenan, bradykinin and kaolin. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9112626

The kinin antagonist hoe 140 reduces acute paw oedema in rats caused by carrageenan, bradykinin and kaolin. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: The kinin antagonist hoe 140 reduces acute paw oedema in rats caused by carrageenan, bradykinin and kaolin. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for The kinin antagonist hoe 140 reduces acute paw oedema in rats caused by carrageenan, bradykinin and kaolin.

AFFILIATION: Department of Pharmacology and Physiology, School of Pharmaceutical Sciences, Universiti Sains Malaysia, 11800, Penang, Malaysia.

Country: Switzerland

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Inflammopharmacology

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

The kinin antagonist hoe 140 reduces acute paw oedema in rats caused by carrageenan, bradykinin and kaolin Related Publications

• BOB.1/OBF.1 controls the balance of TH1 and TH2 immune responses.
• Defining the origin of Plasmodium falciparum resistant dhfr isolates in Senegal.
• Effect of atrial electrical remodeling on the efficacy of antiarrhythmic drugs: comparison of amiodarone with I(Kr)- and I(to)/IKur-blockade in vivo.
• Electromigration of single molecules of DNA in a crystalline array of 300-nm silica colloids.
• High-speed electroseparations inside silica colloidal crystals.
• In vitro expansion of tissue cells by conditional proliferation.
• Incorporating patient self-testing into your practice.
• Interferometric measurements of the surface profile of moving samples.
• Lectin binding studies on C-28/I2 and T/C-28a2 chondrocytes provide a basis for new tissue engineering and drug delivery perspectives in cartilage research.
• Magnetic resonance imaging assessment of spinal inflammation in patients treated for ankylosing spondylitis.
• Mass transport in sub-2-microm high-performance liquid chromatography.
• Materials science. How does radiation damage materials?
• Non-specific association between filamentous bacteria and fungus-growing ants.
• Parsing the motion of single molecules: a novel algorithm for deconvoluting the dynamics of individual receptors at the cell surface.
• Physiological and serological variation in Streptococcus mitis biovar 1 from the human oral cavity during the first year of life.
• Scopolamine in vertigo.
• Separation media for microchips.
• Silica colloidal crystals for enhanced fluorescence detection in microarrays.
• Sintered silica colloidal crystals with fully hydroxylated surfaces.
• The kinin antagonist hoe 140 reduces acute paw oedema in rats caused by carrageenan, bradykinin and kaolin.
• The rationale and role of radiation therapy in the treatment of patients with diffuse large B-cell lymphoma in the Rituximab era.
• The role of DNA mismatch repair in generating genetic diversity and drug resistance in malaria parasites.
• Twenty-year results of combined meniscal allograft transplantation, anterior cruciate ligament reconstruction and advancement of the medial collateral ligament.
• [In Process Citation]
• [In Process Citation]
• [Not Available.]
• [Not Available.]
• [Not Available.]
• [Pharmacology of hibernation.]
• [The influence of nCPAP therapy on the autonomic nervous system dysfunction in OSA patients]