The kinetochore and spindle checkpoint in vertebrate cells.

The kinetochore and spindle checkpoint in vertebrate cells. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

The kinetochore and spindle checkpoint in vertebrate cells. Abstract Text:

Tatsuo Fukagawa,Tatsuo Fukagawa,

The centromere is a specialized region of eukaryotic chromosomes that is essential for faithful chromosome segregation during mitosis and meiosis. A kinetochore is assembled at the centromere of each chromatid of a replicated chromosome and forms a dynamic interface with microtubules of the mitotic spindle. In recent years, many kinetochore proteins have been identified in vertebrate cells. After identification of kinetochore components, the process of kinetochore assembly has been studied. Herein, recent advances in our understanding of the kinetochore and spindle checkpoint in vertebrate cells are reviewed. I also review our recent contributions to this field and discuss their implications using chicken DT40 system.

The kinetochore and spindle checkpoint in vertebrate cells. Publishing Authors By Initials

T Fukagawa,T Fukagawa,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

The kinetochore and spindle checkpoint in vertebrate cells. Journal Published:

PUBLICATION TYPE: Review

Journal: Frontiers in bioscience : a journal and virtual li

VOLUME: 13

Page Numbers: 2705-13

Journal Abbreviation: Front. Biosci.

ISSN: 1093-4715

DAY: 1

MONTH: 01

YEAR: 2008

The kinetochore and spindle checkpoint in vertebrate cells. Information

Number of References: 79

LANGUAGE: eng

NlmUniqueID: 9709506

The kinetochore and spindle checkpoint in vertebrate cells. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: The kinetochore and spindle checkpoint in vertebrate cells. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for The kinetochore and spindle checkpoint in vertebrate cells.

AFFILIATION: Department of Molecular Genetics, National Institute of Genetics and The Graduate University for Advanced Studies, Mishima, Shizuoka 411-8540, Japan. tfukagaw@lab.nig.ac.jp

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Front Biosci

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

The kinetochore and spindle checkpoint in vertebrate cells Related Publications

• A possible role of thioredoxin interacting protein in the pathogenesis of streptozotocin-induced diabetic nephropathy.
• Age-related differences in insulin-like growth factor-1 receptor signaling regulates Akt/FOXO3a and ERK/Fos pathways in vascular smooth muscle cells.
• Alteration of mRNA expression of molecules related to iron metabolism in adenine-induced renal failure rats: a possible mechanism of iron deficiency in chronic kidney disease patients on treatment.
• Bone formation in spontaneously diabetic Torii-newly established model of non-obese type 2 diabetes rats.
• CENP-O Class Proteins Form a Stable Complex and Are Required for Proper Kinetochore Function.
• Down-regulation of manganese-superoxide dismutase through phosphorylation of FOXO3a by Akt in explanted vascular smooth muscle cells from old rats.
• Dynamic behavior of Nuf2-Hec1 complex that localizes to the centrosome and centromere and is essential for mitotic progression in vertebrate cells.
• Histomorphometric analysis of diabetic osteopenia in streptozotocin-induced diabetic mice: a possible role of oxidative stress.
• Protein and energy interactions throughout life. Metabolic basis and nutritional implications.
• Putative role of asymmetric dimethylarginine in microvascular disease of kidney and heart in hypertensive patients.
• Putative role of endothelial lipase in dialysis patients with hypoalbuminemia and inflammation.
• Serum Pro-hepcidin as an Indicator of Iron Status in Dialysis Patients.
• Spontaneous remission of severe hyperparathyroidism with normalization of the reversed whole PTH/intact PTH ratio in a haemodialysis patient.
• The kinetochore and spindle checkpoint in vertebrate cells.
• Treatment of chronic kidney disease-mineral and bone disorder (CKD-MBD).
• Whole or fragmentary information on parathyroid hormone?
• [Basic and Clinical Aspects of Calcimimetics. Calcimimetics : a promising treatment for persistent hypercalcemia after kidney transplantation.]
• [Basic and Clinical Aspects of Calcimimetics. Cinacalcet, effect and mechanisms of action.]
• [Basic and Clinical Aspects of Calcimimetics. Treatment of secondary hyperparathyroidism in dialysis patients with calcimimetics.]
• [The metabolic syndrome and bone health. The Relationship Between Lipid and Glucose Metabolism and Bone Mineral Metabolism : Pleiotropic effects of therapeutic agents for diabetes and hyperlipidemia.]