The kinetics of effect of neuromuscular blocking drugs.

The kinetics of effect of neuromuscular blocking drugs. Research Abstract Details 

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The kinetics of effect of neuromuscular blocking drugs. Abstract Text:

In attempts to derive pharmacokinetic constants from effect data three methods were explored, using non-depolarizing neuromuscular blocking drugs as the paradigm for obtaining effect data. The first method, based on the simple assumption that following two doses, the drug concentrations at times of equal effect during recovery, were equal. Provided that recovery took place in the log-linear drug elimination phase, the elimination rate constant (beta) could be calculated. This method proved rather inaccurate, a second method, again dependent on recovery in the log-linear phase yielded a constant which was the product of beta and the exponent of the Hill equation (s). This method yielded results within 20% of values calculated from plasma drug assays, and it was demonstrated that the time-effect curve could be described from knowledge of this constant. The third method, using non-linear curve fitting technique, derived values for the rate constants of plasma redistribution (alpha) and elimination (beta) as well as for the rate constant of elimination from an effect compartment (keo). If the values were derived from the effect of two doses of a drug, the intensity and duration of effect of a third dose could be predicted with reasonable accuracy. The dose dependent constants of the usual compartmental equations for the plasma concentration of a drug (A and B) could be derived in terms of the EC50. The method can be applied to any drug whose effect can be measured and whose maximal effect can be defined. We believe that the method may be useful in rapidly and inexpensively estimating population kinetic parameters, and in screening drugs.

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The kinetics of effect of neuromuscular blocking drugs. Journal Published:

PUBLICATION TYPE: Review

Journal: The Keio journal of medicine

VOLUME: 43

Page Numbers: 27-30

Journal Abbreviation: Keio J Med

ISSN: 0022-9717

DAY: 7

MONTH: Mar

YEAR: 1994

The kinetics of effect of neuromuscular blocking drugs. Information

Number of References: 7

LANGUAGE: eng

NlmUniqueID: 376354

The kinetics of effect of neuromuscular blocking drugs. Keywords Mesh Terms:

KEYWORDS: Time Factors

MESH TERMS: pharmacokinetics

Chemical & Substance for Abstract: The kinetics of effect of neuromuscular blocking drugs. Information

Substance Name: Neuromuscular Nondepolarizing Agents

Registry Number: 0

Grant and Affiliation Information for The kinetics of effect of neuromuscular blocking drugs.

AFFILIATION: Department of Anaesthesia and Intensive Care, Prince Henry Hospital, Little Bay, NSW, Australia.

Country: JAPAN

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MEDLINETA: Keio J Med

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