[The killing effect of IL-2 and IFN-alpha activated bone marrow on K562 leukemic cell]

[The killing effect of IL-2 and IFN-alpha activated bone marrow on K562 leukemic cell] Research Abstract Details 

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[The killing effect of IL-2 and IFN-alpha activated bone marrow on K562 leukemic cell] Abstract Text:

C Li,W Yan,Y Hao,S Feng,L Qiu,H Liu,J Han,X Li,S Feng,

OBJECTIVE: To evaluate the killing effect of IL-2 and IFN-alpha activated bone marrow cells on K562 cells. METHODS: Semi-solid colony assay was used. RESULTS: Bone marrow from leukemia patients in remission was activated in vitro with IL-2 for 3 days. The activated bone marrow (ABM) displayed killing effects of 0.31 approximately 2.30 logs on K562 cells, this killing effects was further increased to 0. 30 approximately > 3.15 logs when IFN-alpha added with IL-2 to the marrow for activation. IL-2 alone or in combination with IFN-alpha showed no inhibition of CFU-GM and K562 cells. Compared with IL-2 or IFN-alpha alone, the combination of the two cytokines could more effectively maintain the killing effect of ABM on leukemic cells. CONCLUSION: IFN-alpha can augment the purging effect of IL-2 ABM and combination of the two cytokines can effectively maintain the cytotoxicity of ABM.

[The killing effect of IL-2 and IFN-alpha activated bone marrow on K562 leukemic cell] Publishing Authors By Initials

C Li,W Yan,Y Hao,S Feng,L Qiu,H Liu,J Han,X Li,S Feng,

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[The killing effect of IL-2 and IFN-alpha activated bone marrow on K562 leukemic cell] Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Zhonghua xue ye xue za zhi = Zhonghua xueyexue zaz

VOLUME: 18

Page Numbers: 410-2

Journal Abbreviation: Zhonghua Xue Ye Xue Za Zhi

ISSN: 0253-2727

DAY: 31

MONTH: Aug

YEAR: 1997

[The killing effect of IL-2 and IFN-alpha activated bone marrow on K562 leukemic cell] Information

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LANGUAGE: chi

NlmUniqueID: 8212398

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AFFILIATION: Institute of Hematology and Blood Diseases Hospital, CAMS and PUMC, Tianjin 300020.

Country: China

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MEDLINETA: Zhonghua Xue Ye Xue Za Zhi

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