The Killer Immunoglobulin-Like Receptor (KIR) Group A Haplotype is Associated With Bronchiolitis Obliterans Syndrome After Lung Transplantation.

The Killer Immunoglobulin-Like Receptor (KIR) Group A Haplotype is Associated With Bronchiolitis Obliterans Syndrome After Lung Transplantation. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

The Killer Immunoglobulin-Like Receptor (KIR) Group A Haplotype is Associated With Bronchiolitis Obliterans Syndrome After Lung Transplantation. Abstract Text:

BACKGROUND: The development of bronchiolitis obliterans syndrome (BOS) after lung transplantation is associated with viral infections. Natural killer (NK) cells are involved in the lysis of viral infected cells, and their activation is largely controlled by activating and inhibitory killer immunoglobulin-like receptors (KIRs). We hypothesized that KIR ligand incompatibility and recipients' individual KIRs could influence the development of BOS and the incidence of cytomegalovirus reactivation after lung transplantation. METHODS: The KIR gene contents were determined in 48 patients who received a lung transplant, and human leukocyte antigen (HLA)-Cw and HLA-Bw4 typing was performed on their respective donors. RESULTS: BOS developed in 7 patients and cytomegalovirus reactivation occurred in 16. BOS developed in 5 of 19 patients homozygous for KIR haplotype A compared with 2 of 27 patients with KIR haplotype AB and B (homozygous; p = 0.03; log-rank test). In none of the patients with BOS was the activating KIR2DS5 gene detected, whereas it was present in 35% of patients without BOS (p = 0.04; log-rank test). No correlation was found between KIR gene content and cytomegalovirus reactivation. CONCLUSION: Our results suggest that the lack of activating KIRs may play an important role in the development of BOS but not in the control of cytomegalovirus reactivation after lung transplantation.

The Killer Immunoglobulin-Like Receptor (KIR) Group A Haplotype is Associated With Bronchiolitis Obliterans Syndrome After Lung Transplantation. Publishing Authors By Initials

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

The Killer Immunoglobulin-Like Receptor (KIR) Group A Haplotype is Associated With Bronchiolitis Obliterans Syndrome After Lung Transplantation. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: The Journal of heart and lung transplantation : th

VOLUME: 27

Page Numbers: 995-1001

Journal Abbreviation: J. Heart Lung Transplant.

ISSN: 1557-3117

DAY: 3

MONTH: Sep

YEAR: 2008

The Killer Immunoglobulin-Like Receptor (KIR) Group A Haplotype is Associated With Bronchiolitis Obliterans Syndrome After Lung Transplantation. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9102703

The Killer Immunoglobulin-Like Receptor (KIR) Group A Haplotype is Associated With Bronchiolitis Obliterans Syndrome After Lung Transplantation. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: The Killer Immunoglobulin-Like Receptor (KIR) Group A Haplotype is Associated With Bronchiolitis Obliterans Syndrome After Lung Transplantation. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for The Killer Immunoglobulin-Like Receptor (KIR) Group A Haplotype is Associated With Bronchiolitis Obliterans Syndrome After Lung Transplantation.

AFFILIATION: Heart Lung Center Utrecht, University Medical Center Utrecht, Utrecht, The Netherlands.

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: J Heart Lung Transplant

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

The Killer Immunoglobulin-Like Receptor KIR Group A Haplotype is Associated With Bronchiolitis Obliterans Syndrome After Lung Transplantation Related Publications

• A canadian perspective.
• A fungal growth model fitted to carbon-limited dynamics of Rhizoctonia solani.
• A visual pitfall: Persistent Mullerian duct syndrome (PMDS).
• Analysis of the antimicrobial activity of local anaesthetics used for dental analgesia.
• Biologic markers in neuroblastoma.
• Case files of the university of cincinnati fellowship in medical toxicology: two patients with acute lethal occupational exposure to hydrogen sulfide.
• Chronic, infantile, neurological, cutaneous, and articular syndrome in a neonate: a case report.
• Controlling propulsive forces in gait initiation in transfemoral amputees.
• Hyperpolarized gases--a new type of MR contrast agents?
• Illegitimacy moderates the effects of power on approach.
• Maxillomandibular fixation with Otten mini-hooks.
• Measurement and data-processing approach for estimating the spatial statistics of turbulence-induced index of refraction fluctuations in the upper atmosphere.
• Methodology issues in lipid pharmacoeconomic investigations. Reactor panel and open forum.
• Multi-joint dynamics and the development of movement control.
• Nerve growth factor as a mediator of information between effector organs and innervating neurons.
• Prevalence of testicular adrenal rest tumours in male children with congenital adrenal hyperplasia due to 21-hydroxylase deficiency.
• Proprioceptive coordination of movement sequences in humans.
• Purpose in life in patients with rheumatoid arthritis.
• Response to growth hormone treatment and final height in Noonan syndrome in a large cohort of patients in the KIGS database.
• Stress-induced secretion of ACTH and corticosterone during development of spontaneous hypertension in rats.
• The Killer Immunoglobulin-Like Receptor (KIR) Group A Haplotype is Associated With Bronchiolitis Obliterans Syndrome After Lung Transplantation.
• The motor system: the whole and its parts.
• Towards automated diffraction tomography. Part II-Cell parameter determination.
• Unresolved maternal attachment representations, disrupted maternal behavior and disorganized attachment in infancy: links to toddler behavior problems.
• [Effects of war conditions on the frequency and the course of certain internal diseases.]
• [Experiences with MUMPS in the development of a laboratory system]
• [Intradermoreactions to histoplasmin in a Congolese population as compared with coccidioidin, blastomycin and tuberculin.]
• [Results of treatment with growth hormones in children with classical growth hormone deficiency]
• [Visceral leishmaniasis: a possible diagnosis in Belgium]