The JAK/STAT pathway regulates proximo-distal patterning in Drosophila.

The JAK/STAT pathway regulates proximo-distal patterning in Drosophila. Research Abstract Details 

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The JAK/STAT pathway regulates proximo-distal patterning in Drosophila. Abstract Text:

Aidee Ayala-Camargo,Laura A Ekas,Maria Sol Flaherty,Gyeong-Hun Baeg,Erika A Bach,Aidee Ayala-Camargo,Laura A Ekas,Maria Sol Flaherty,Gyeong-Hun Baeg,Erika A Bach,

JAK/STAT signaling is thought to control growth and proliferation. However, here we show a novel role for this pathway in the patterning of Drosophila appendages. Loss of Stat92E function results mainly in ventralizations and multiplications of the proximo-distal axis in leg and antenna, primarily through the ectopic misexpression of wingless. We also show that the pathway ligand Unpaired is expressed in two domains in leg and antenna that abuts those of wingless and decapentaplegic. We report that JAK/STAT signaling represses both wingless and decapentaplegic, restricting them to their respective domains in leg and antenna. In a reciprocal manner, we show that wingless and decapentaplegic restrict unpaired to its two domains. Thus, a main function of the JAK/STAT pathway in leg and antennal development is to promote the formation of a single proximo-distal axis per disc by constraining the intersection of wingless and decapentaplegic to the center of the disc.

The JAK/STAT pathway regulates proximo-distal patterning in Drosophila. Publishing Authors By Initials

A Ayala-Camargo,LA Ekas,MS Flaherty,GH Baeg,EA Bach,A Ayala-Camargo,LA Ekas,MS Flaherty,GH Baeg,EA Bach,

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The JAK/STAT pathway regulates proximo-distal patterning in Drosophila. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Developmental dynamics : an official publication o

VOLUME: 236

Page Numbers: 2721-30

Journal Abbreviation: Dev. Dyn.

ISSN: 1058-8388

DAY: 1

MONTH: Oct

YEAR: 2007

The JAK/STAT pathway regulates proximo-distal patterning in Drosophila. Information

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LANGUAGE: eng

NlmUniqueID: 9201927

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Grant and Affiliation Information for The JAK/STAT pathway regulates proximo-distal patterning in Drosophila.

AFFILIATION: Pharmacology Department, New York University School of Medicine, New York, New York 10016-6402, USA.

Country: United States

AGENCY: United States NIGMS

GRANT: GM066704-01

ACRONYM: GM

MEDLINETA: Dev Dyn

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