The involvement of physico-chemical interactions in the adhesion of Candida albicans and Candida dubliniensis to epithelial cells.

The involvement of physico-chemical interactions in the adhesion of Candida albicans and Candida dubliniensis to epithelial cells. Research Abstract Details 

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The involvement of physico-chemical interactions in the adhesion of Candida albicans and Candida dubliniensis to epithelial cells. Abstract Text:

Mariana Henriques,Joana Azeredo, Oliveira,Mariana Henriques,Joana Azeredo, Oliveira,

Candida albicans and Candida dubliniensis are two pathogenic yeasts particularly hazardous to immunocompromised patients. Adhesion of yeast cells to epithelium is considered one of the virulence factors and its study is of major importance. The main aim of this study was the comparison of the influence of physico-chemical properties on the adhesion of C. albicans and C. dubliniensis to epithelium. Two strains of each Candida species were used in the adhesion assays to HeLa cells. Adhered cells were enumerated by direct microscopic images observation. Yeast cell surface tension parameters and degree of hydrophobicity were determined by contact angle measurement. Pseudohyphae and hyphae formation was analysed by scanning electron microscopy. Yeast cells presented no statistical differences concerning their physico-chemical surface properties. However, the extent of adhesion to epithelium was different among the four strains. As general conclusion, yeast adhesion to epithelium seems to be strain-dependent and not directly correlated with pseudohyphae formation.

The involvement of physico-chemical interactions in the adhesion of Candida albicans and Candida dubliniensis to epithelial cells. Publishing Authors By Initials

M Henriques,J Azeredo,R Oliveira,M Henriques,J Azeredo,R Oliveira,

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The involvement of physico-chemical interactions in the adhesion of Candida albicans and Candida dubliniensis to epithelial cells. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Mycoses

VOLUME: 50

Page Numbers: 391-6

Journal Abbreviation: Mycoses

ISSN: 0933-7407

DAY: 23

MONTH: Sep

YEAR: 2007

The involvement of physico-chemical interactions in the adhesion of Candida albicans and Candida dubliniensis to epithelial cells. Information

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LANGUAGE: eng

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Grant and Affiliation Information for The involvement of physico-chemical interactions in the adhesion of Candida albicans and Candida dubliniensis to epithelial cells.

AFFILIATION: Centro de Engenharia Biológica, Universidade do Minho, Campus Gualtar, Braga, Portugal. mcrh@deb.uminho.pt

Country: Germany

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MEDLINETA: Mycoses

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