The involvement of non-B DNA structures in gross chromosomal rearrangements.

The involvement of non-B DNA structures in gross chromosomal rearrangements. Research Abstract Details 

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The involvement of non-B DNA structures in gross chromosomal rearrangements. Abstract Text:

Albino Bacolla,Marzena Wojciechowska,Beata Kosmider,Jacquelynn E Larson,Robert D Wells,

Non-B DNA conformations adopted by certain types of DNA sequences promote genetic instabilities, especially gross rearrangements including translocations. We conclude the following: (a) slipped (hairpin) structures, cruciforms, triplexes, tetraplexes and i-motifs, and left-handed Z-DNA are formed in chromosomes and elicit profound genetic consequences via recombination-repair, (b) repeating sequences, probably in their non-B conformations, cause gross genomic rearrangements (translocations, deletions, insertions, inversions, and duplications), and (c) these rearrangements are the genetic basis for numerous human diseases including polycystic kidney disease, adrenoleukodystrophy, follicular lymphomas, and spermatogenic failure.

The involvement of non-B DNA structures in gross chromosomal rearrangements. Publishing Authors By Initials

A Bacolla,M Wojciechowska,B Kosmider,JE Larson,RD Wells,

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The involvement of non-B DNA structures in gross chromosomal rearrangements. Journal Published:

PUBLICATION TYPE: Review

Journal: DNA repair

VOLUME: 5

Page Numbers: 1161-70

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ISSN: 1568-7864

DAY: 27

MONTH: 06

YEAR: 2006

The involvement of non-B DNA structures in gross chromosomal rearrangements. Information

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LANGUAGE: eng

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AFFILIATION: Institute of Biosciences and Technology, Center for Genome Research, The Texas A&M University System Health Science Center, Texas Medical Center, 2121 West Holcombe Blvd., Houston, TX 77030, USA. abacolla@ibt.tamhsc.edu

Country: Netherlands

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MEDLINETA: DNA Repair (Amst)

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