The introductory placebo washout: a retrospective evaluation.

The introductory placebo washout: a retrospective evaluation. Research Abstract Details 

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The introductory placebo washout: a retrospective evaluation. Abstract Text:

We examined the effects of the "introductory placebo washout" technique by reanalyzing the results of a recent trial of an experimental antidepressant. At the beginning, all patients were placed on placebo in a single-blind design. Patients who were rated as placebo responders with the physician-administered Hamilton Rating Scale for Depression (HRSD) were excluded from the trial. In spite of this technique, an alternative measure of depression indicated that many patients with a positive response to placebo had been entered in the trial. In the reanalysis, elimination of these "hidden placebo responders" did not lower the final placebo response rate and actually diminished the differences observed at the end of the study between the active treatment and placebo groups. These data suggest that the introductory placebo washout may have unpredictable, possibly confounding effects on patient samples in trials of antidepressant agents.

The introductory placebo washout: a retrospective evaluation. Publishing Authors By Initials

For similar behavioral disciplines and activities: psychiatric status rating scales research abstracts see: behavioral disciplines and activities: psychiatric status rating scales research

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The introductory placebo washout: a retrospective evaluation. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Psychiatry research

VOLUME: 30

Page Numbers: 191-9

Journal Abbreviation: Psychiatry Res

ISSN: 0165-1781

DAY: 17

MONTH: Nov

YEAR: 1989

The introductory placebo washout: a retrospective evaluation. Information

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LANGUAGE: eng

NlmUniqueID: 7911385

The introductory placebo washout: a retrospective evaluation. Keywords Mesh Terms:

KEYWORDS: Psychiatric Status Rating Scales

MESH TERMS: therapeutic use

Chemical & Substance for Abstract: The introductory placebo washout: a retrospective evaluation. Information

Substance Name: Fluoxetine

Registry Number: 54910-89-3

Grant and Affiliation Information for The introductory placebo washout: a retrospective evaluation.

AFFILIATION: Department of Psychiatry, University of Utah Medical Center, Salt Lake City 84132.

Country: IRELAND

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MEDLINETA: Psychiatry Res

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