The intriguing prion disorders.

The intriguing prion disorders. Research Abstract Details 

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The intriguing prion disorders. Abstract Text:

K Abid,C Soto,

Prion diseases are among the most intriguing illnesses. Despite their rare incidence, they have captured enormous attention from the scientific community and general public. One of the most hotly debated issues in these diseases is the nature of the infectious material. In recent years increasing evidence has emerged supporting the protein-only hypothesis of prion transmission. In this model PrPSc (the pathological isoform of the prion protein, PrPC) represents the sole component of the infectious particle. However, uncertainties about possible additional factors involved in the conversion of PrPC into PrPSc remain despite extensive attempts to isolate and characterize these elusive components. In this article, we review recent developments concerning the protein-only hypothesis as well as the possible involvement of cellular factors in PrPC to PrPSc conformational change and their influence on the pathogenesis of prion diseases.

The intriguing prion disorders. Publishing Authors By Initials

K Abid,C Soto,

For similar proteins: protein isoforms research abstracts see: proteins: protein isoforms research

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The intriguing prion disorders. Journal Published:

PUBLICATION TYPE: Review

Journal: Cellular and molecular life sciences : CMLS

VOLUME: 63

Page Numbers: 2342-51

Journal Abbreviation: Cell. Mol. Life Sci.

ISSN: 1420-682X

DAY: 3

MONTH: Oct

YEAR: 2006

The intriguing prion disorders. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9705402

The intriguing prion disorders. Keywords Mesh Terms:

KEYWORDS: Protein Isoforms

MESH TERMS: physiology

Chemical & Substance for Abstract: The intriguing prion disorders. Information

Substance Name: Protein Isoforms

Registry Number: 0

Grant and Affiliation Information for The intriguing prion disorders.

AFFILIATION: Protein Misfolding Disorders Lab, George and Cynthia Mitchell Center for Alzheimer's Disease Research, Department of Neurology, Neuroscience and Cell Biology, University of Texas Medical Branch, 301 University Blvd, Galveston, Texas 77555, USA.

Country: Switzerland

AGENCY: United States NINDS

GRANT: NS050349

ACRONYM: NS

MEDLINETA: Cell Mol Life Sci

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