The Interleukin-1 receptor antagonist is a direct target gene of PPARalpha in liver.

The Interleukin-1 receptor antagonist is a direct target gene of PPARalpha in liver. Research Abstract Details 

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The Interleukin-1 receptor antagonist is a direct target gene of PPARalpha in liver. Abstract Text:

Rinke Stienstra, Mandard,Nguan Soon Tan,Walter Wahli,Christian Trautwein,Terrilyn A Richardson,Elgin Lichtenauer-Kaligis,Sander Kersten,Michael ,

BACKGROUND/AIMS: The Peroxisome Proliferator-Activated Receptor (PPAR) alpha belongs to the superfamily of Nuclear Receptors and plays an important role in numerous cellular processes, including lipid metabolism. It is known that PPARalpha also has an anti-inflammatory effect, which is mainly achieved by down-regulating pro-inflammatory genes. The objective of this study was to further characterize the role of PPARalpha in inflammatory gene regulation in liver. RESULTS: According to Affymetrix micro-array analysis, the expression of various inflammatory genes in liver was decreased by treatment of mice with the synthetic PPARalpha agonist Wy14643 in a PPARalpha-dependent manner. In contrast, expression of Interleukin-1 receptor antagonist (IL-1ra), which was acutely stimulated by LPS treatment, was induced by PPARalpha. Up-regulation of IL-1ra by LPS was lower in PPARalpha -/- mice compared to Wt mice. Transactivation and chromatin immunoprecipitation studies identified IL-1ra as a direct positive target gene of PPARalpha with a functional PPRE present in the promoter. Up-regulation of IL-1ra by PPARalpha was conserved in human HepG2 hepatoma cells and the human monocyte/macrophage THP-1 cell line. CONCLUSIONS: In addition to down-regulating expression of pro-inflammatory genes, PPARalpha suppresses the inflammatory response by direct up-regulation of genes with anti-inflammatory properties.

The Interleukin-1 receptor antagonist is a direct target gene of PPARalpha in liver. Publishing Authors By Initials

R Stienstra,S Mandard,NS Tan,W Wahli,C Trautwein,TA Richardson,E Lichtenauer-Kaligis,S Kersten,M ,

For similar genetic processes: gene expression regulation: up-regulation research abstracts see: genetic processes: gene expression regulation: up-regulation research

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The Interleukin-1 receptor antagonist is a direct target gene of PPARalpha in liver. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of hepatology

VOLUME: 46

Page Numbers: 869-77

Journal Abbreviation:

ISSN: 0168-8278

DAY: 26

MONTH: 12

YEAR: 2006

The Interleukin-1 receptor antagonist is a direct target gene of PPARalpha in liver. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8503886

The Interleukin-1 receptor antagonist is a direct target gene of PPARalpha in liver. Keywords Mesh Terms:

KEYWORDS: Up-Regulation

MESH TERMS: genetics

Chemical & Substance for Abstract: The Interleukin-1 receptor antagonist is a direct target gene of PPARalpha in liver. Information

Substance Name: pirinixic acid

Registry Number: 50892-23-4

Grant and Affiliation Information for The Interleukin-1 receptor antagonist is a direct target gene of PPARalpha in liver.

AFFILIATION: Nutrition, Metabolism and Genomics Group, Division of Human Nutrition, Wageningen University, The Netherlands.

Country: England

AGENCY: United States NIGMS

GRANT: GM46897

ACRONYM: GM

MEDLINETA: J Hepatol

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