The interferon-alpha gene family of Marmota himalayana, a Chinese marmot species with susceptibility to woodchuck hepatitis virus infection.

The interferon-alpha gene family of Marmota himalayana, a Chinese marmot species with susceptibility to woodchuck hepatitis virus infection. Research Abstract Details 

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The interferon-alpha gene family of Marmota himalayana, a Chinese marmot species with susceptibility to woodchuck hepatitis virus infection. Abstract Text:

Yinping Lu,Baoju Wang,Hongping Huang,Yongjun Tian,Junjie Bao,Jihua Dong,Michael Roggendorf,Mengji Lu,Dongliang Yang,

The interferon-alpha (IFN-alpha) gene family is an important part of the immune system. Recombinant interferon-alpha is widely used to treat viral hepatitis and malignant diseases. Marmota himalayana has been found to be susceptible to woodchuck hepatitis virus, a virus genetically related to hepatitis B virus (HBV), and is suitable as an animal model for studies on HBV infection. Here, the IFN-alpha gene family of M. himalayana (cwIFN-alpha) was characterized. Sequence data indicate that the cwIFN-alpha family consists of at least 8 functional sequences and 6 pseudogenes with high homology within the family and to IFN-alpha of Marmota monax, a related species and well-established animal model. The recombinant cwIFN-alpha subtypes were expressed and tested to be active in viral protection assay and to induce expression of MxA in a species-specific manner. This work provides essential information for future work on testing new therapeutic approaches of HBV infection based on IFN-alpha in M. himalayana.

The interferon-alpha gene family of Marmota himalayana, a Chinese marmot species with susceptibility to woodchuck hepatitis virus infection. Publishing Authors By Initials

Y Lu,B Wang,H Huang,Y Tian,J Bao,J Dong,M Roggendorf,M Lu,D Yang,

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The interferon-alpha gene family of Marmota himalayana, a Chinese marmot species with susceptibility to woodchuck hepatitis virus infection. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Developmental and comparative immunology

VOLUME: 32

Page Numbers: 445-57

Journal Abbreviation: Dev. Comp. Immunol.

ISSN: 0145-305X

DAY: 22

MONTH: 10

YEAR: 2007

The interferon-alpha gene family of Marmota himalayana, a Chinese marmot species with susceptibility to woodchuck hepatitis virus infection. Information

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LANGUAGE: eng

NlmUniqueID: 7708205

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Grant and Affiliation Information for The interferon-alpha gene family of Marmota himalayana, a Chinese marmot species with susceptibility to woodchuck hepatitis virus infection.

AFFILIATION: Division of Clinical Immunology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China.

Country: United States

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MEDLINETA: Dev Comp Immunol

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