The interactive effects of extended wakefulness and low-dose alcohol on simulated driving and vigilance.

The interactive effects of extended wakefulness and low-dose alcohol on simulated driving and vigilance. Research Abstract Details 

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The interactive effects of extended wakefulness and low-dose alcohol on simulated driving and vigilance. Abstract Text:

Mark E Howard,Melinda L Jackson,Gerard A Kennedy,Philip Swann,Maree Barnes,Robert J Pierce,Mark E Howard,Melinda L Jackson,Gerard A Kennedy,Philip Swann,Maree Barnes,Robert J Pierce,

OBJECTIVES: Sleep deprivation and alcohol both impair driving performance. This study assessed the interactive effect of low-dose alcohol and extended wakefulness. DESIGN: Repeated-measures, crossover design evaluating psychomotor and driving function in a non-sleep-deprived state and after extended wakefulness with and without low-dose alcohol. SETTING: Teaching hospital sleep laboratory. PARTICIPANTS: Nineteen volunteer professional drivers. INTERVENTION & MEASUREMENTS: Driving simulation (AusEd) and the Psychomotor Vigilance Task (PVT) were measured in a rested state (12-15 hours awake) and after extended wakefulness (18-21 hours awake) during two sessions. Alcohol was administered during one session, with performance measured at blood alcohol concentrations (BAC) of 0.00%, 0.03%, and 0.05% in a non-sleep-deprived state, and at 0.03% after extended wakefulness (at 01:00 and 03:00). During the second session, tests were performed at the same times without alcohol. RESULTS: The combination of extended wakefulness and low-dose alcohol had significant deleterious effects on reaction time and lapses (PVT) and variation in lane position and speed (AusEd). Extended wakefulness (18-21 hours awake) combined with low-dose alcohol (0.03% BAC) resulted in more lapses (t = -2.75, P < 0.05) and greater variation in lane position (t = -3.94, P < 0.01) and speed (t = -2.79, P < 0.05) than did a BAC of 0.05% in a rested state. CONCLUSION: The combination of legal low-dose alcohol and extended wakefulness results in impairment worse than that at an alcohol level known to increase accident risk. Avoiding alcohol when driving after extended wakefulness may reduce accident risk.

The interactive effects of extended wakefulness and low-dose alcohol on simulated driving and vigilance. Publishing Authors By Initials

ME Howard,ML Jackson,GA Kennedy,P Swann,M Barnes,RJ Pierce,ME Howard,ML Jackson,GA Kennedy,P Swann,M Barnes,RJ Pierce,

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The interactive effects of extended wakefulness and low-dose alcohol on simulated driving and vigilance. Journal Published:

PUBLICATION TYPE: Randomized Controlled Trial

Journal: Sleep

VOLUME: 30

Page Numbers: 1334-40

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ISSN: 0161-8105

DAY: 1

MONTH: Oct

YEAR: 2007

The interactive effects of extended wakefulness and low-dose alcohol on simulated driving and vigilance. Information

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LANGUAGE: eng

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AFFILIATION: Institute for Breathing & Sleep, Department of Respiratory & Sleep Medicine, Austin Health, Melbourne, Australia. mark.howard@austin.org.au

Country: United States

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MEDLINETA: Sleep

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