[The influence of postburn administration of rhGH on the host inflammatory response]

[The influence of postburn administration of rhGH on the host inflammatory response] Research Abstract Details 

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[The influence of postburn administration of rhGH on the host inflammatory response] Abstract Text:

Qin Zhang,Zhen-jiang Liao,Xin Wang,Jian Liu,Zai-ming Jin,Li-jv Xu,

OBJECTIVE: To investigate the changes in the systemic inflammatory response and T cell induced immunity after systemic administration of recombinant human growth hormone (rhGH) during early postburn stage. METHODS: Forty Sprague-Dawley (SD) rats were randomly divided into three groups for the study. The rats in control group (C, n = 6) were only used for the determination of plasma levels of the cytokines, such as TNFalpha, IL-2, IL-6 and CD4(+) and CD8(+) cells. The SD rats in burn with rhGH treatment group (BT, n = 18) and burn without treatment group (B, n = 18) were inflicted with III degree scalding injury on the back. rhGH was injected subcutaneously on the abdomen of the rats in a dose of 6 IU/kg for 10 days in BT group. The blood samples were harvested from the rats in the two groups for the evaluation of the above indices. RESULTS: The plasma levels of TNFalpha, IL-2, IL-6 and CD4(+) and CD8(+) cells were increased on the 3(rd) postburn day (PBD) and decreased on the 6(th) PBD in B group, while the CD4(+) and CD8(+) cells were increased significantly and the plasma levels of TNFalpha, IL-2, IL-6 decreased obviously on the 3(rd) PBD in BT group. And the plasma levels of IL-2 and IL-6 in BT group on the 6(th) PBD showed no difference from those in C group. But the plasma TNFalpha level in BT group was evidently higher than that in B and C group on the 6(th) PBD. Furthermore, the plasma levels of TNFalpha, IL-2 and IL-6 in BT group were still increased gradually on the 10(th) PBD, while the IL-2 and IL-6 levels were decreased obviously in B group, but the TNFalpha level was increased. CONCLUSION: Systemic administration of rhGH during different states of stress exerted different effects on T cell induced immunity and systemic inflammatory response.

[The influence of postburn administration of rhGH on the host inflammatory response] Publishing Authors By Initials

Q Zhang,ZJ Liao,X Wang,J Liu,ZM Jin,LJ Xu,

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[The influence of postburn administration of rhGH on the host inflammatory response] Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Zhonghua shao shang za zhi = Zhonghua shaoshang za

VOLUME: 19

Page Numbers: 216-8

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ISSN: 1009-2587

DAY: 29

MONTH: Aug

YEAR: 2003

[The influence of postburn administration of rhGH on the host inflammatory response] Information

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LANGUAGE: chi

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Grant and Affiliation Information for [The influence of postburn administration of rhGH on the host inflammatory response]

AFFILIATION: Department of Burns, Rui Jin Hospital, The Second Medical University of Shanghai, PR China.

Country: China

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MEDLINETA: Zhonghua Shao Shang Za Zhi

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