The influence of patient adherence on anticoagulation control with warfarin: results from the International Normalized Ratio Adherence and Genetics (IN-RANGE) Study.

The influence of patient adherence on anticoagulation control with warfarin: results from the International Normalized Ratio Adherence and Genetics (IN-RANGE) Study. Research Abstract Details 

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The influence of patient adherence on anticoagulation control with warfarin: results from the International Normalized Ratio Adherence and Genetics (IN-RANGE) Study. Abstract Text:

Stephen E Kimmel,Zhen Chen,Maureen Price,Catherine S Parker,Joshua P Metlay,Jason D Christie,Colleen M Brensinger,Craig W Newcomb,Frederick F Samaha,Robert Gross,

BACKGROUND: Warfarin sodium is a highly efficacious drug, but proper levels of anticoagulation are difficult to maintain. Conflicting data exist on the influence of patient adherence on anticoagulation control. METHODS: We performed a prospective cohort study at 3 anticoagulation clinics to determine the effect of adherence on anticoagulation control. Patients treated with warfarin with a target international normalized ratio of 2.0 to 3.0 were monitored with electronic Medication Event Monitoring System (MEMS) medication bottle caps. Detailed information was collected on other factors that might alter warfarin response. RESULTS: Among 136 participants observed for a mean of 32 weeks, 92% had at least 1 missed or extra bottle opening; 36% missed more than 20% of their bottle openings; and 4% had more than 10% extra bottle openings. In multivariable analyses, there was a significant association between underadherence and underanticoagulation. For each 10% increase in missed pill bottle openings, there was a 14% increase in the odds of underanticoagulation (P<.001); participants with more than 20% missed bottle openings (1-2 missed days each week) had more than a 2-fold increase in the odds of underanticoagulation (adjusted odds ratio, 2.10; 95% confidence interval, 1.48-2.96). Participants who had extra pill bottle openings on more than 10% of days had a statistically significant increase in overanticoagulation (adjusted odds ratio, 1.73; 95% confidence interval, 1.09-2.74). CONCLUSION: Patients have substantial difficulties maintaining adequate adherence with warfarin regimens, and this poor adherence has a significant effect on anticoagulation control.

The influence of patient adherence on anticoagulation control with warfarin: results from the International Normalized Ratio Adherence and Genetics (IN-RANGE) Study. Publishing Authors By Initials

SE Kimmel,Z Chen,M Price,CS Parker,JP Metlay,JD Christie,CM Brensinger,CW Newcomb,FF Samaha,R Gross,

For similar heterocyclic compounds: heterocyclic compounds, 2-ring: benzopyrans: coumarins: 4-hydroxycoumarins: warfarin research abstracts see: heterocyclic compounds: heterocyclic compounds, 2-ring: benzopyrans: coumarins: 4-hydroxycoumarins: warfarin research

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The influence of patient adherence on anticoagulation control with warfarin: results from the International Normalized Ratio Adherence and Genetics (IN-RANGE) Study. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Archives of internal medicine

VOLUME: 167

Page Numbers: 229-35

Journal Abbreviation: Arch. Intern. Med.

ISSN: 0003-9926

DAY: 12

MONTH: Feb

YEAR: 2007

The influence of patient adherence on anticoagulation control with warfarin: results from the International Normalized Ratio Adherence and Genetics (IN-RANGE) Study. Information

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LANGUAGE: eng

NlmUniqueID: 372440

The influence of patient adherence on anticoagulation control with warfarin: results from the International Normalized Ratio Adherence and Genetics (IN-RANGE) Study. Keywords Mesh Terms:

KEYWORDS: Warfarin

MESH TERMS: administration & dosage

Chemical & Substance for Abstract: The influence of patient adherence on anticoagulation control with warfarin: results from the International Normalized Ratio Adherence and Genetics (IN-RANGE) Study. Information

Substance Name: Warfarin

Registry Number: 81-81-2

Grant and Affiliation Information for The influence of patient adherence on anticoagulation control with warfarin: results from the International Normalized Ratio Adherence and Genetics (IN-RANGE) Study.

AFFILIATION: Department of Medicine, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, 423 Guardian Drive, Philadelphia, PA 19104, USA. skimmel@cceb.med.upenn.edu

Country: United States

AGENCY: United States NHLBI

GRANT: R01 HL 066176-04

ACRONYM: HL

MEDLINETA: Arch Intern Med

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