[The influence of native ribonucleases and their modified derivatives on the functional activity of rat peritoneal macrophages]

[The influence of native ribonucleases and their modified derivatives on the functional activity of rat peritoneal macrophages] Research Abstract Details 

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[The influence of native ribonucleases and their modified derivatives on the functional activity of rat peritoneal macrophages] Abstract Text:

N V Kalacheva,B M Kurinenko,

The influence of native, hydrophobized and dimeric forms of ribonucleases (RNAse A and RNAse Bacillus intermedius) on the process of phagocytosis and fusion between lysosomes and phagosomes in rat macrophages has been studied. The effect of native RNAses depends on their concentration: comparatively low concentrations (0.5-50 microg ml(-1)) stimulate the phagocytosis and phagosome-lysosome fusion whereas high concentrations (above 75 microg ml(-1)) inhibit these processes. RNAses modified by surfactant oxanol-KD-6 and dimeric forms of RNAses possess only the inhibitory effect, which appears at concentration considerably lower than that of native enzymes. The stimulatory effect of native RNAses and the inhibitory effect of hydrophobized derivatives do not depend on the catalytic activity.

[The influence of native ribonucleases and their modified derivatives on the functional activity of rat peritoneal macrophages] Publishing Authors By Initials

NV Kalacheva,BM Kurinenko,

For similar fungi: yeasts research abstracts see: fungi: yeasts research

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[The influence of native ribonucleases and their modified derivatives on the functional activity of rat peritoneal macrophages] Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Biomedit?sinskai?a khimii?a

VOLUME: 51

Page Numbers: 303-10

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ISSN:

DAY: 3

MONTH: 04

YEAR: 2008

[The influence of native ribonucleases and their modified derivatives on the functional activity of rat peritoneal macrophages] Information

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LANGUAGE: rus

NlmUniqueID: 101196966

[The influence of native ribonucleases and their modified derivatives on the functional activity of rat peritoneal macrophages] Keywords Mesh Terms:

KEYWORDS: Yeasts

MESH TERMS: physiology

Chemical & Substance for Abstract: [The influence of native ribonucleases and their modified derivatives on the functional activity of rat peritoneal macrophages] Information

Substance Name: Ribonuclease, Pancreatic

Registry Number: EC 3.1.27.5

Grant and Affiliation Information for [The influence of native ribonucleases and their modified derivatives on the functional activity of rat peritoneal macrophages]

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Country: Russia (Federation)

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MEDLINETA: Biomed Khim

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