The influence of inducible costimulator fusion protein (ICOSIg) gene transfer on corneal allograft survival.

The influence of inducible costimulator fusion protein (ICOSIg) gene transfer on corneal allograft survival. Research Abstract Details 

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The influence of inducible costimulator fusion protein (ICOSIg) gene transfer on corneal allograft survival. Abstract Text:

Daniel Fabian,Nianqiao Gong,Katrin Vogt,Hans-Dieter Volk,Uwe Pleyer,Thomas Ritter,Daniel Fabian,Nianqiao Gong,Katrin Vogt,Hans-Dieter Volk,Uwe Pleyer,Thomas Ritter,Daniel Fabian,Nianqiao Gong,Katrin Vogt,Hans-Dieter Volk,Uwe Pleyer,Thomas Ritter,

BACKGROUND: The purpose of this paper is to analyse the effects of local or systemic administration of adenovirus type 5 encoding the inducible costimulator fusion protein (AdICOSIg) on its influence on prolonging corneal allograft survival. METHODS: The ICOSIg chimeric molecule was generated by fusing the murine ICOS to a rat FcIgG portion and a recombinant adenovirus (Ad) was made thereof. A major histocompatibility complex (MHC) class I/II mismatched rat corneal transplant model was used. The recipients were randomly assigned to receive ex vivo gene-modified corneas expressing either ICOSIg or a single i.p. injection (1.0 x 10(9) infectious particles) of AdICOSIg two days after transplantation and graft survival was analysed. Moreover, the influence of ICOSIg fusion protein on anti-adenovirus immunity also was investigated. RESULTS: The ex vivo gene transfer of ICOSIg in cultured corneas resulted in high levels of ICOSIg protein in culture supernatants. However, neither ex vivo nor systemic gene therapy resulted in a significant prolongation of graft survival. Interestingly, the generation of anti-adenovirus antibodies could not be inhibited by systemic ICOSIg fusion protein expression. CONCLUSIONS: Unlike CTLA4Ig, sole ICOSIg gene therapy is not a successful strategy for the prevention of allogeneic graft rejection in corneal transplantation.

The influence of inducible costimulator fusion protein (ICOSIg) gene transfer on corneal allograft survival. Publishing Authors By Initials

D Fabian,N Gong,K Vogt,HD Volk,U Pleyer,T Ritter,D Fabian,N Gong,K Vogt,HD Volk,U Pleyer,T Ritter,D Fabian,N Gong,K Vogt,HD Volk,U Pleyer,T Ritter,

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The influence of inducible costimulator fusion protein (ICOSIg) gene transfer on corneal allograft survival. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Graefe's archive for clinical and experimental oph

VOLUME: 245

Page Numbers: 1515-21

Journal Abbreviation: Graefes Arch. Clin. Exp. Ophth

ISSN: 0721-832X

DAY: 6

MONTH: 07

YEAR: 2007

The influence of inducible costimulator fusion protein (ICOSIg) gene transfer on corneal allograft survival. Information

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LANGUAGE: eng

NlmUniqueID: 8205248

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AFFILIATION: Institute of Medical Immunology, Charité-University Medicine Berlin, Berlin, Germany.

Country: Germany

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MEDLINETA: Graefes Arch Clin Exp Ophthalm

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