The influence of gliomas and nonglial space-occupying lesions on blood-oxygen-level-dependent contrast enhancement.

The influence of gliomas and nonglial space-occupying lesions on blood-oxygen-level-dependent contrast enhancement. Research Abstract Details 

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The influence of gliomas and nonglial space-occupying lesions on blood-oxygen-level-dependent contrast enhancement. Abstract Text:

A Schreiber,U Hubbe,S Ziyeh,J Hennig,

BACKGROUND AND PURPOSE: Functional MR (fMR) imaging with blood-oxygen-level-dependent (BOLD) contrast enhancement is increasingly used as a noninvasive tool for presurgical mapping in patients with intracranial tumors. Most physiologic studies of task-related BOLD contrast enhancement have involved healthy volunteers. Therefore, it is not known whether BOLD contrast is evoked in the same way in or adjacent to tumor tissue. The purpose of this study was to study the influence of different intracranial tumors on BOLD contrast enhancement. METHODS: fMR mapping of the sensorimotor cortex was successfully performed in 15 of 21 patients with intracranial space-occupying lesions by using a bimanual motor task. Tumors were located either within the sensorimotor area itself or in adjacent brain areas, inducing changes of signal intensity on T2-weighted images along the pre- or postcentral gyrus. Space-occupying lesions were divided into a group comprising gliomas (seven cases) and a group comprising nonglial space-occupying lesions (three metastases, two cavernomas, one abscess, one arteriovenous malformation, one meningioma). A hemispheric activation index was calculated using the volume of activation on the affected and on the contralateral hemisphere. Hemispheric activation indices of gliomas and nonglial lesions were compared statistically. RESULTS: The activated volume in the hemispheres ipsilateral to the nonglial lesions was 14% larger than in the contralateral hemisphere, whereas in the hemispheres ipsilateral to gliomas, the activated volume decreased by 36% in comparison with the contralateral hemisphere. The difference between nonglial lesions and gliomas was significant (P < .05). CONCLUSION: The generation of BOLD contrast enhancement is reduced near gliomas but is not affected by nonglial tumors.

The influence of gliomas and nonglial space-occupying lesions on blood-oxygen-level-dependent contrast enhancement. Publishing Authors By Initials

A Schreiber,U Hubbe,S Ziyeh,J Hennig,

For similar nervous system: central nervous system: brain: prosencephalon: telencephalon: cerebrum: cerebral cortex: parietal lobe: somatosensory cortex research abstracts see: nervous system: central nervous system: brain: prosencephalon: telencephalon: cerebrum: cerebral cortex: parietal lobe: somatosensory cortex research

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The influence of gliomas and nonglial space-occupying lesions on blood-oxygen-level-dependent contrast enhancement. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: AJNR. American journal of neuroradiology

VOLUME: 21

Page Numbers: 1055-63

Journal Abbreviation:

ISSN: 0195-6108

DAY: 14

MONTH: 02

YEAR: 2008

The influence of gliomas and nonglial space-occupying lesions on blood-oxygen-level-dependent contrast enhancement. Information

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LANGUAGE: eng

NlmUniqueID: 8003708

The influence of gliomas and nonglial space-occupying lesions on blood-oxygen-level-dependent contrast enhancement. Keywords Mesh Terms:

KEYWORDS: Somatosensory Cortex

MESH TERMS: physiopathology

Chemical & Substance for Abstract: The influence of gliomas and nonglial space-occupying lesions on blood-oxygen-level-dependent contrast enhancement. Information

Substance Name: Oxygen

Registry Number: 7782-44-7

Grant and Affiliation Information for The influence of gliomas and nonglial space-occupying lesions on blood-oxygen-level-dependent contrast enhancement.

AFFILIATION: Department of Neurology, Albert-Ludwigs-University, Freiburg, Germany.

Country: UNITED STATES

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MEDLINETA: AJNR Am J Neuroradiol

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